树鼩应用于丙型肝炎病毒相关领域的研究进展  

Progress in Researches on Application of Tree Shrews to the Relevant Field of Hepatitis C Virus

作　　者：匡德宣[1] 江勤芳[1] 孙晓梅[1] 仝品芬[1] 高家红[1] 陆彩霞[1] 代解杰[1] 

机构地区：[1]中国医学科学院/北京协和医学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,昆明650118

出　　处：《实验动物科学》2013年第1期55-60,共6页Laboratory Animal Science

基　　金："十一五"国家科技支撑计划项目(No.2009BAI83B02-21;2011BAI15B01-21;2012BAI39B01);云南省科技基础条件平台建设计划项目(No.2006PT07-2);云南省应用基础面上项目(No.2011FZ211)

摘　　要：丙型肝炎病毒慢性感染已成为世界范围的公共健康问题,由于缺少合适的丙型肝炎病毒研究模型,所以对丙肝病毒感染机制、生活周期和致病机制的研究进展较为缓慢。树鼩属于低等的灵长类动物,许多生物学特性近似于人类。近年来引起医学生物界和相关管理部门的重视和关注,国内外的学者在树鼩是否可作为丙型肝炎病毒感染的动物模型方面作过十分有益的尝试。本文介绍了国内外树鼩应用于丙型肝炎病毒模型研究的进展情况及应用前景。Persistent infection with hepatitis C virus （HCV） has become a global public health problem. The lack of proper study models has brought difficulties in the study of the mechanism of viral infection, life cycle and pathogenic mechanism of HCV. Tree shrews are classified into the primate animal and many biological characteristics are close to human. In recent years, Tree shrews has aroused the common interest in the biomedical researchers and the relevant regulators. The domestic and foreign scholars have made many positive attempts in order to determine whether or not tree shrews is used as the model of HCV infection. This article will introduce the newly progress of application of tree shrew in HCV experimental model research.

关 键 词：树鼩 丙型肝炎病毒 体内外感染 受体 

分 类 号：R332[医药卫生—人体生理学] R373.21[医药卫生—基础医学]