OPCML蛋白在上皮性卵巢癌中的表达及意义  

THE EXPRESSION AND SIGNIFICANCE OF OPCML PROTEIN IN PRIMARY EPITHELIAL OVARIAN CANCER

作　　者：童红洲 胡宾[2] 沈敬华[2] 

机构地区：[1]湖南省赤山监狱医院,湖南沅江413103 [2]内蒙古医科大学免疫教研室

出　　处：《内蒙古医科大学学报》2013年第2期142-145,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自然科学基金项目(200508010925)

摘　　要：目的:探讨OPCML蛋白表达水平与上皮性卵巢癌发生相关关系及其意义。方法:应用westernblotting技术检测8例正常卵巢8例良性卵巢肿瘤6例交界性卵巢肿瘤和36例上皮性卵巢癌组织中OPCML蛋白表达。结果:OPCML蛋白表达率在正常卵巢和良性卵巢肿瘤为100%,上皮性卵巢癌33.3%和交界性卵巢肿瘤66.7%,相比明显减低(P<0.05),OPCML蛋白相对含量在上皮性卵巢癌和交界性卵巢癌组织中分别为0.63±0.47和1.10±0.40低于正常卵巢(1.66±0.31)和卵巢良性肿瘤(1.52±0.30),卵巢癌中蛋白相对含量均与肿瘤分期呈负相关(P<0.05),而与病理类型和组织分级无关(P>0.05)。结论:OPCML蛋白表达与上皮性卵巢癌的发生、发展密切相关,可作为卵巢癌生物学行为的重要指标。Objective： To explore the mechanism and significance of OPCML in ovarian epithelial cancer. Methods：The expression levels of OPCML protein were evaluated by using western-blotting in 8 cases of normal ovarian tissues, 8 cases benign ovarian tumor,6 cases of ovarian borderline tumor and 36 cases of ovarian epithelial cancer. Results： The expression rates and of OPCML protein in normal tissues and benign ovarian tumor were both 100% ,in tissues of ovarian epithelial cancer and borderline ovarian tumor were separately 33.3 % and 66.7 %, which were significantly lower than that （P〈0.05）. The expression of intensities of OPCML protein in ovarian epithelial cancer and borderline ovarian tumor were 0.63 ±0.47 and 1.10 ±0.40, which were significantly lower than that in normal tissues （ 1.66± 0.31 ） and benign ovarian tumor （ 1.52 ±0.30 ） （ P 〈 0.05 ）. Ovarian cancer was negatively correlated with surgical- phatological staging and had nothing to do with hislogical grading or pathological types（ P〉0.05 ）. Conclusion：We can find that OPCML may play important roles in carci- nogenesis, development, and invasion of ovarian epithelial cancer and it can be think as an important marker of biological behaviors of ovarian cancer.

关 键 词：OPCML 上皮性卵巢癌 WESTERN BLOTTING 

分 类 号：R392.11[医药卫生—免疫学]