连翘颗粒剂的急性亚急性毒性试验研究  

Research of Acute and Subacute Toxicity for Forsythiae Granules

作　　者：吴悦[1] 陈俭清[1] 赵玉莲[1] 李贤贤[1] 李鹤[1] 李艳华[1] 

机构地区：[1]东北农业大学动物医学院,哈尔滨150030

出　　处：《中国兽药杂志》2013年第4期23-26,共4页Chinese Journal of Veterinary Drug

基　　金："十二五"农村领域国家科技计划课题"防治猪流感中兽药的研制与开发"国家科技支撑项目(2011BAD34B01-03)

摘　　要：为了评价连翘颗粒剂的安全性,对其进行了急性、亚急性毒性试验研究。首先,急性毒性试验确定最大给药剂量为100 g/kg;亚急性毒性试验选用昆明小鼠80只随机分为四组:对照组及连翘各剂量组(100 g/kg、33.3 g/kg、10 g/kg),分别在给药的第7日和第14日时,对各组小鼠进行一般症状观察并分别检测血液中的血红蛋白、红细胞数、白细胞数和血清中的谷草转氨酶(GOT)、谷丙转氨酶(GPT)、肌酐(CR)、尿素氮(BUN)和碱性磷酸酶(AKP)。结果表明,各项指标与正常组相比无显著差异,连翘颗粒剂的毒性较低,临床用药安全可靠。In order to evaluate the security of forsythiae granules, the acute and subacute toxicity of forsythiae granules was tested in mice. The acute toxicity test selected 100 g/kg as the maximum dosage firstly. The subacute toxicity test used 80 mice, randomly divided into four groups： control group, forsythiae granules each does groups （ 100 g/kg, 33.3 g/kg, 10 g/kg）. At the 7 th day and the 14 th day of giving medicines, the common symptom of the mice was observed in each group. Then detection hemoglobin, erythrocytes number, leukocyte number and glutamic oxaloacetic transaminase （GOT） ,glutamic - pyruvic transaminase （ GPT）, creatinine （ CR）, blood urea nitrogen （BUN）, alkaline phosphatase （AKP） in serum. The results showed that the blood physiological and biochemical indexes compared with the normal group were no significant differences. It also demonstrated that the forsythiae granules had lower toxicity and were safety for clinical apphcation.

关 键 词：连翘颗粒剂 昆明系小鼠 急性毒性试验 亚急性毒性试验 

分 类 号：S853.74[农业科学—临床兽医学]