我院铜绿假单胞菌医院感染现状及耐药性分析  

Pseudomonas aeruginosa nosocomial infection status and drug resistance analysis in our hospital

作　　者：王晓君[1,2] 应斌松 

机构地区：[1]浙江省绍兴市人民医院 [2]浙江大学绍兴医院药剂科,绍兴312000 [3]浙江省绍兴市第五医院药剂科,绍兴312000

出　　处：《中国临床药学杂志》2013年第2期97-99,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的分析铜绿假单胞菌医院感染的现状及耐药性,为合理用药提供参考。方法细菌鉴定应用美国MicroScan WalkAway-965I全自动微生物分析仪,药敏试验采用K-B纸片扩散法,用WHONET 5.4软件进行统计分析。结果493株铜绿假单胞菌主要分布在重症监护病房(ICU),占30.42%;其次为呼吸内科,占25.15%。标本来源主要为痰液,占57.81%;其次为脓液及分泌物,占17.85%。铜绿假单胞菌对哌拉西林他唑巴坦、哌拉西林、亚胺培南、左氧氟沙星、美洛培南、替卡西林克拉维酸的耐药率较高,均>45.0%;对多黏菌素B和阿米卡星的耐药率较低,分别为0.20%和9.13%。结论铜绿假单胞菌是医院感染的主要病原菌之一,需对其加强耐药性监测。AIM To investigate the infection status and drug resistance of Pseudomonas aeruginosa in nosocomial infections to provide reference for clinicians in rational drug use. METHODS The isolated bacteria were identified by MicroScan WalkAway-96SI automatic microorganism analyzer and the sensitivity test was performed by adopting Kirby Bauer method. The data were analyzed by WHONET 5.4 software. RESULTS Totally 493 strains of Pseudomonas aeruginosa were mainly isolated from the intensive care unit （30.42%）,and the next was respiratory ward （25.15%）. Among all the specimens, sputum accounted for 57.81%, and the pus and secretions accounted for 17.85 %. The higher drug resistant rates of Pseudomonas aeruginosa strains to piperacillin/tazobactam, piperacillin, imipenem, levofloxacin, meropenem, ticarcillin/clavulanate were found, and the resistance rate was greater than 45 %. The lower drug resistance rates to polymyxin B were 0.20% and to amikacin were 9.13% ,respectively. CONCLUSION Pseudomonas aeruginosa is the major pathogenic bacteria in nosocomial infection. The surveillance to antimicrobial resistance is very important for guiding the rational application of antimicrobial drugs and controlling the prevalence of nosocomial infection.

关 键 词：铜绿假单胞菌 医院感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]