面部热刺激痛的功能性磁共振成像研究  

Cortical representation of heat induced facial pain:evidence from fMRI

作　　者：李家[1] 刘洪臣[2] 李科[3] 金真[3] 龚娟[1] 

机构地区：[1]同济大学附属口腔医院口腔生物医学及转化医学实验室,上海200072 [2]解放军总医院口腔医学研究所 [3]解放军306医院

出　　处：《现代口腔医学杂志》2013年第2期70-73,共4页Journal of Modern Stomatology

基　　金：国家自然科学基金资助项目(30772450)

摘　　要：目的明确面部皮肤热刺激痛引起的大脑中枢反应区。方法选取6名健康志愿者。热痛刺激右侧面部V2区,并采用GE-EPI扫描序列和热痛刺激-常温刺激(on/off)的block设计方法,采集全脑血氧水平依赖对比的fMRI扫描数据,以SPM99软件包进行结果的数据分析获得面部皮肤热痛刺激与常温刺激对比的脑功能图像。结果热痛刺激引起双侧前扣带回(ACC)、岛叶,对侧顶叶中央后回、额下回、小脑,同侧顶下小叶、颞上回激活。其中对侧前扣带回和中央后回有强烈广泛的激活。结论①面痛激活脑区与以往有关躯体痛觉研究的脑功能成像结果基本符合,即ACC、岛叶/SII、前额叶、顶叶、小脑参与面痛的中枢传导。②面痛刺激引起的对侧大脑半球激活比同侧更强。Objective To evaluate the neural cortical response to facial skin heat stimulated pain. Methods 6 right handed healthy volunteers participated in the study. Heat pain stimuli was applied to right side of right side of face： maxillary trigeminal division, and block designed BOLD functional MRI scan covering the whole brain was carried out. The fMRI data were analyzed by SPM99 software to generate the activation map. Results Increased BOLD signals during heat stimulation were found in bilateral anterior cingulated cortex （ACC）, insula/SII, contralateral posteentral gyrus, inferior frontal gyms, cerebellum, ipsilateral superior temporal gyrus, inferior parietal lobule. The contralateral activation in ACC and insula/SII were stronger than that in ipsilateral side. Conclusion （1） Brain activation of facial pain agrees with previous neuroimaging findings in somatotopie pain perception, including insula/SII, ACC, PFC, parietal lobe, cerebellum. （2）The facial pain evoked a stronger activation of contralateral hemisphere than ipsilateral hemisphere.

关 键 词：颌面部 疼痛 热 皮质 功能性磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]