高压氧治疗噪声性听损的实验研究  

EXPERIMENTAL STUDY ON NOISE HEARING DAMAGE BY HYPERBARIC OXYGEN THERAPY

作　　者：王国山[1] 何冬宁[2] 徐锡坤[2] 顾立铭[1] 姚宏伟[1] 

机构地区：[1]南京医科大学第三附属医院,江苏仪征211900 [2]南京医科大学劳动卫生研究室,江苏南京210029

出　　处：《职业卫生与应急救援》2000年第3期119-121,共3页Occupational Health and Emergency Rescue

摘　　要：目的探讨高压氧治疗噪声性听力损伤的作用机理和疗效。方法将声损伤豚鼠分别进行高压氧（Ｉ）、复方丹参（Ⅱ）、高压氧＋复方丹参（Ⅲ）治疗。疗程结束后测定脑干听阈诱发电位听阈的变化及耳蜗的葡萄糖、丙酮酸含量。结果葡萄糖含量噪声损伤组低于对照组，高压氧组（Ⅰ）高于噪声损伤组；丙酮酸含量噪声损伤组与其它组均有差异；丙酮酸／葡萄糖比值高压氧组（Ⅰ）、高压氧＋丹参组（Ⅲ）均低于噪声损伤组，噪声损伤组高于对照组。高压氧组（ Ⅰ）听力损失１ ２．５ｄＢ（Ａ），高压氧＋丹参组（Ⅲ）听力损伤仅为 ２．５ｄＢ（Ａ）。结论高压氧治疗噪声性听力损伤有肯定的疗效，高压氧＋丹参治疗噪声性听力损伤有协同作用，而丹参单独治疗尚不能认为有效。Objective To study the mechanisms of action and the curative effect of the hyperbaric oxygen treating the noiseinduced hearing impairment. Methods Hearing impaired guinea pigs were treated separately with hyperbaric oxygen (Ⅰ). radix salviae miltiorrhiza co ( Ⅱ ), hyperbaric oxygen and radix salviae miltiorrhiza co (Ⅲ). Measure the audition threshold change of the brain stem audition area evoked potential; and the content of the glucose and pyruvic acid in the cochlea were measured after the end of treatment. Results The content of the glucose: the impaired group is lower than the control group, the ( Ⅰ ) group is higher than the impaired group. The content of the pyruvic acid: the impaired group is different with all the other groups. The ratio of pyruvic acid/glucose: (Ⅰ) group and (Ⅲ) group both are lower than the impaired group, the impaired group is higher than the control group. The hearing impairment of (Ⅰ) group is 12.5dB(A), while that of (Ⅲ) group is only 2.5dB(A). Conclusion Treating the noise-induced hearing impairment with hyperbaric oxygen has a definite curative effect, the hyperbaric oxygen and radix salviae miltiorrhiza co together has a synergism, and the radix salviae miltiorrhiza co alone can't be effective surely.

关 键 词：噪声 高压氧 复方丹参 治疗 

分 类 号：R135.8[医药卫生—劳动卫生]