远端肾单位离子转运及调控机制  

Mechanisms of distal nephron ion transport and regulation

作　　者：茆俊花[1] 李建中[1] 戴春笋[1] 

机构地区：[1]南京医科大学第二附属医院肾脏科,南京210009

出　　处：《肾脏病与透析肾移植杂志》2013年第1期53-56,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：远曲小管、连接小管及集合管组成位于致密斑远端的远端肾单位,是调控肾脏离子转运的重要组成部分。远端肾单位离子转运功能失调与临床上多种疾病(如高血压、假性醛固酮减少症等)的发生发展密切相关。准确了解远端肾单位离子转运及其分子调控机制有助更好地理解相关疾病的发病机制。本文就远端肾单位Na+、K+和Cl-转运及调控机制的最新研究进展作一综述。Distal nephron is composed of DCT, CNT, and CD,which plays a critical role in regulating kidney ion transport. The discovery of WNKs and claudins points to the underlying mechanisms that dictate Na ＋ , K ＋ and C1- transport in the distal nephron. They should be understood in order to fully comprehend the pathophysiology, manifestations, and treatment of many clinical entities such as hypovolemic shock, congestive heart failure, primary hyperaldosteronism, pseudo- hypoaldosteronism and hypertension et al. Here the underlying molecular mechanisms that dictate Na＋, K＋ and Cl- handling in the distal nephron is reviewed.

关 键 词：远端肾单位 离子转运 调控机制 

分 类 号：R692[医药卫生—泌尿科学]