顺铂加5-氟脲嘧啶治疗恶性腹水的疗效观察  

Therapeutic evaluation of cisplatin plus 5 fluorouracil in malignant ascitic fluid

作　　者：袁云芳[1] 

机构地区：[1]河南省肿瘤医院核医学科,河南郑州450003

出　　处：《河南医学研究》2000年第3期258-259,共2页Henan Medical Research

摘　　要：目的 :观察应用顺铂 (DDP)加 5 氟脲嘧啶 ( 5 FU)治疗恶性腹水效果。方法 :先将腹水尽量抽尽 ,然后将DDP 10 0mg加生理盐水 3 0 0ml、5 FU 10 0 0mg、胃复安 3 0mg、地塞米松 (DXM) 2 0mg依次注入腹腔内。结果 :40例患者中 ,CR2 4例 ( 60 %) ;PR12例 ( 3 0 %) ,总有效率 90 %。结论 :DDP加 5 FU应用治疗恶新和腹水有效率高 ,毒副反应轻 。Objective:?To observe therapeutic effectiveness of cisplatin plus 5 fluorouracil in malignant ascites. Methods:After pumping ascitic fluid throughly, cisplatin (dosage in 100 mg) and physiological saline (dosage in 300 ml), 5 flurouracil (dosage in 1000 mg), metoclopramide (dosage in 30 mg), dexamethasone (dosage in 20 mg) were injected in abdominal cavity in turn. Results:?In 40 cases, complete regression (CR) was 24 cases (60%), partial regression was 12 cases (30%), effective rate was 90%. Conclusion: The regimen of cisplatin plus 5 fluorouracil has high effective rate and minor side effect. It has practical value of extending to clinical application.

关 键 词：恶性腹水 DDP5-FU 腹腔注入 治疗 

分 类 号：R442.5[医药卫生—诊断学]