畅脉舒对家兔动脉粥样硬化的防治作用  

Experiment Study On Effect of Changmaishu in Treating Rabbits of Experimental Atherosclerosis

作　　者：刘同美[1] 王家富[1] 王建英[1] 宋秀媛[1] 段文卓[1] 丁怡[1] 郭方明[1] 李寿花[1] 

机构地区：[1]潍坊医学院病理生理学教研室,山东潍坊261042

出　　处：《潍坊医学院学报》2000年第3期161-162,共2页Acta Academiae Medicinae Weifang

基　　金：山东省中医管理局科研基金资助课题! (No.930 36)

摘　　要：目的　探讨畅脉舒防治动脉粥样硬化 (AS)的作用机制。方法　采用高胆固醇饲料喂养 ,建立家兔 AS模型 ,随机分为对照组、模型组、地奥心血康组 (地奥组 )和畅脉舒用药组 ,每组在实验第 1 4周取血标本测定血脂、血清一氧化氮 (NO)、血浆内皮素 (ET)、环鸟苷酸 (c GMP)、脂质过氧化物 (L PO)和超氧化物歧化酶 (SOD)等指标。结果　与模型组比较 ,畅脉舒及地奥组 1 3周后均能提高 NO,c GMP,高密度脂蛋白 (HDL - C)含量和 SOD活性 (P<0 .0 5 ,P<0 .0 1 ) ,降低ET,L PO,L DL - C、甘油三酯 (TG)、总胆固醇 (TC)和低密度脂蛋白 (L DL - C)含量 (P<0 .0 1 ) ,并且在降低 ET和 L PO,升高NO,c GMP含量及 SOD活性方面优于地奥心血康组 (P<0 .0 5 )。结论　畅脉舒可以有效地降低血脂 ,减少动脉粥样硬化斑块形成 ,是防治动脉粥样硬化有效的复方中药制剂。Objective To explore the therapeutic effect and mechanism of Changmaishu(CMS) in treating atherosclerosis(AS).Method An atherosclerotic rabbits model was established by feeding high cholesterol diet.The rabbits were randomly divided into the control,model,Di’aoxinxuekang(DK) and CMS treated groups.Blood samples were collected 13 weeks after relevant treatment.The effect of treatment on plasma lipids,nitric oxide (NO),endothelin (ET),cyclic guanosine monophosphate (cGMP),lipid peroxide (LPO) and superoxide dismutase (SOD) activity indexes were observed.Result After 13 weeks,CMS and DK administration,compared with model group,the NO,cGMP,high densitylipoprotein (HDL) and activity of SOD increased (P<0.05 or P<0.01).While ET,LPO,total cholesterol(TC),triglyceride (TG) and low density lipoprotein (LDL) decreased (P<0.01).The effects of CMS is similar to DK,and the effect of CMS on decreasing ET and LPO,and on increasing NO,cGMP and activity of SOD in plasma are more powerful than those of DK(P<0.05).Conclusion The CMS possesses the effects of regulating blood lipids,antioxidation,treated atherosclerosis. [

关 键 词：动脉继样硬化 血脂 一氧化氮 畅脉舒 药理 治疗 

分 类 号：R543.505[医药卫生—心血管疾病] R286.26[医药卫生—内科学]