畅脉舒对动脉粥样硬化家兔血浆一氧化氮、血浆内皮素和血脂的影响  

Effect of Changmaishu on Nitric Oxide,Endothelin and Plasma Lipids in Experimental Atherosclerotic Rabbits

作　　者：王家富[1] 刘同美[1] 丁怡 宋秀媛 段文卓 王建英 郭方明 李寿花 

机构地区：[1]泰山医学院病理生理学教研室,山东潍坊261042

出　　处：《潍坊医学院学报》2000年第3期163-164,共2页Acta Academiae Medicinae Weifang

基　　金：山东省中医管理局科研基金资助课题 !(No.930 36)

摘　　要：目的　观察畅脉舒预防用药对动脉粥样硬化家兔一氧化氮 (NO)、血浆内皮素 (ET)和血脂的影响。方法　采用高胆固醇喂养 ,建立家兔 AS模型 ,随机分为对照组、模型组和畅脉舒用药组 ,每组在实验第 1 4周取血标本测定上述指标。结果　与模型组比较 ,畅脉舒组能提高 NO、高密度脂蛋白 (HDL )含量 (P<0 .0 5 ,P<0 .0 1 ) ,降低 ET、总胆固醇、甘油三酯和低密度脂蛋白含量 (P<0 .0 1 )。结论　畅脉舒具有调节血脂、保护内皮功能和维持Objective To observe the effects of Changmaishu (CMS) on nitric oxide (NO),endothelin(ET)and plasma lipids in experimental atherosclerotic rabbits.Method An atherosclerotic rabbit model was fed high cholesterol diet.The rabbits were randomly divided into the control,model and CMS treated groups.Blood samples were collected after 13 weeks relevant treatment.Result After 13 weeks,CMS administration compared with model group,the NO and high density lipoprotein (HDL) increased (P<0.05;P<0.01),while ET,total cholesterol (TC),triglyceride (TG) and low density lipoprotein (LDL) decreased (P<0.01).Conclusion The CMS has the effects of regulating blood lipids,preserving endlothelial function,and maintaining the balance of NO/ET. [

关 键 词：动脉粥样硬化 内皮素 畅脉舒 治疗 药理 NO 

分 类 号：R543.505[医药卫生—心血管疾病] R286.26[医药卫生—内科学]