Luminol-K_3Fe(CN)_6 chemiluminescence system for the determination of glipizide  

作　　者：Xin Chen Li-Li Xing Yu-Hai Tang Guang-Bin Zhang 

机构地区：[1]The 405 Hospital of Hanzhong City,Hanzhong [2]Institute of Analytical Sciences,Xi'an Jiaotong University

出　　处：《Journal of Pharmaceutical Analysis》2013年第2期127-131,共5页药物分析学报（英文版）

基　　金：financial support from Institute of Analytical Sciences,Xi'an

摘　　要：A rapid and sensitive flow-injection chemiluminescence（CL） method for the determination of glipizide was developed on the basis of finding that glipizide can enhance the CL intensity of the luminol-K3Fe（CN）6 system.In optimum condition,the increased CL intensity was directly proportional to the concentration of glipizide in the range from 4.0×108 g/mL to 1.0×106 g/mL and the detection limit was 1.0×108 g/mL glipizide.The relative standard deviation（RSD） of the developed method was 2.1% with 11 repeated measurements of 1.0×107 g/mL glipizide.The developed method has been successfully applied to the analysis of glipizide in its pharmaceutical preparations.A rapid and sensitive flow-injection chemiluminescence（CL） method for the determination of glipizide was developed on the basis of finding that glipizide can enhance the CL intensity of the luminol-K3Fe（CN）6 system.In optimum condition,the increased CL intensity was directly proportional to the concentration of glipizide in the range from 4.0×108 g/mL to 1.0×106 g/mL and the detection limit was 1.0×108 g/mL glipizide.The relative standard deviation（RSD） of the developed method was 2.1% with 11 repeated measurements of 1.0×107 g/mL glipizide.The developed method has been successfully applied to the analysis of glipizide in its pharmaceutical preparations.

关 键 词：Luminol-K 3 Fe（CN） 6 Glipizide Flow injection Chemiluminescence 

分 类 号：R927[医药卫生—药学]