间充质干细胞系统：解析机体免疫调控和代谢平衡  

Concept of Mesenchymal Stem Cells: Bring More Insights into Functional Research of MSC

作　　者：赵春华[1] 

机构地区：[1]北京协和医学院、中国医学科学院基础医学研究所组织工程中心,协和医院,北京100000

出　　处：《中国实验血液学杂志》2013年第2期263-267,共5页Journal of Experimental Hematology

基　　金：国家重大科学研究计划(973)(编号2011CB964900);国家863项目(编号2011AA020100)

摘　　要：间充质干细胞由于其独特的生物学特性和临床应用潜能,一直是干细胞研究的热点。这里,我首次提出间充质干细胞系统新概念:自胚胎发育早期,经历整个生长发育全过程的不同胚层、多个发育阶段,将亚全能间充质干细胞到不同等级分化潜能间充质干/祖细胞群体统称为MSC系统。MSC系统的确立具有重要意义:(1)赋予了MSC三大重要生物学特征,即干细胞自身特性、组织微环境功能及免疫调控功能;(2)平衡机体免疫与组织代谢;(3)提供高效转化为临床安全有效的组织特异性干细胞。总之,该系统很好的解释了间充质干细胞的异质性,同时丰富了我们之前提出的亚全能干细胞理论,为研究人员更好的理解间充质干细胞提供了深厚的理论平台。Mesenchymal stem cells have generated great interest among researchers and physicians due to their unique biological characteristics and potential clinical applications. Here, I propose for the first time the concept of a hierarchical system which is composed of all mesenchymal stem cells from post-embryonic subtotipotent stem cells to MSC progenitors. Post-embryonic subtotipotent stem cells are left-over ceils during embryonic development and are on the top of the hierarchy. MSC system is a combination of cells that are derived from different stages of embryonic development, possess different differentiation potential and ultimately give rise to cells that share a similar set of phenotypic markers. The concept of MSC system has important implications ： （i） it entirely explains the three important biological characteristics of MSC： stem cell properties of MSC, MSC as components of tissue microenvironment and immunomodulatory functions of MSC. （~）It balances immune responses and tissue metabolism. （~）It could provide tissue- specific stem cells for clinical application with high efficiency and safety. In a word, this concept constitutes an important part of the biological properties of MSC and will help researchers gain better insight into MSC.

关 键 词：干细胞 间充质干细胞 间充质干细胞系统 

分 类 号：R331.2[医药卫生—人体生理学]