CD_(68)在狼疮肾炎肾组织中表达的初步探讨  

Preliminary Study on CD_(68) Expression in Kidney Tissues of Patients With Lupus Nephritis

作　　者：侯玲[1] 卫建平[1] 吴丽然[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《山西中医学院学报》2013年第1期52-54,共3页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:观察在狼疮肾炎(LN)肾组织中巨噬细胞特异性抗体CD68的表达,探讨巨噬细胞与LN肾脏病理的相关性。方法:通过免疫组织化学技术检测48例LN患者的肾活检标本中巨噬细胞特异性抗体CD68的表达。结果:正常肾组织中CD68基本不表达或偶见表达,而在LN肾组织中CD68表达明显增强,差异有统计学意义(P<0.01);巨噬细胞在肾小球内的浸润与在肾小管间质内的浸润成正相关(P<0.01)。结论:巨噬细胞可能是LN肾小球和肾小管间质病变的重要参与者,巨噬细胞浸润与LN病情的进展可能有关。Objective：To explore the relevance between macrophages and pathological changes of renal through observing macrophage specific antibody CD68 expression in renal tissue of patients with lupus nephritis（LN）.Methods：CD68 expression in renal biopsy specimens of 48 patients with LN was detected by immunohistochemical techniques.Results：In normal kidney tissue,CD68 basically did not express or occasionally expressed.CD68 expression was significantly increased in the renal tissue of patients with LN（P0.01）,infiltration of macrophages in renal glomerulus and infiltration of macrophages in interstitium of renal tubules had a positive correlation（P0.01）.Conclusion：Macrophage may participate pathological changes of renal glomerulus and interstitium of renal tubules,and macrophage has ties with progression of pathogenetic condition of LN.

关 键 词：狼疮肾炎 巨噬细胞 肾间质病变 

分 类 号：R593.242[医药卫生—内科学]