贝前列素钠对糖尿病肾病尿白蛋白/肌酐比值及血管内皮功能的影响  

Effect of baraprost sodium on urinary-to-albumin creatinine ratio and vascular endothelial function in patients with diabetic nephropathy

作　　者：周卫华[1] 张玉娜[1] 刘桂红[1] 

机构地区：[1]河北医科大学第四医院内分泌科,050011

出　　处：《疑难病杂志》2013年第5期349-351,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察贝前列素钠对早期糖尿病肾病尿白蛋白/肌酐比值(UACR)及血管内皮功能的影响。方法 2型糖尿病肾病(DN)Ⅲ期患者64例,随机分为2组:对照组32例口服厄贝沙坦150 mg/次,每日1次;治疗组32例口服厄贝沙坦150 mg/次(每日1次)+贝前列素钠40μg/次(每日3次),疗程均为4周。评估2组治疗前后UACR、血浆同型半胱氨酸(Hcy)、血浆内皮素(ET-1)和血清一氧化氮(NO)的变化。结果与治疗前比较,2组治疗后UACR(mg/g)均下降(治疗组212±121 vs 111±56,对照组214±125 vs 168±65,均为P<0.05);且治疗组下降较对照组更为明显(P<0.05);治疗组的Hcy、ET-1降低,NO明显升高,分别为[(19.0±3.2)μmol/L vs(14.2±2.6)μmol/L;(79.1±9.9)ng/L vs(45.2±9.2)ng/L;(47.6±8.5)μmol/L vs(89.0±9.4)μmol/L,均为P<0.05],而对照组无显著改善(P>0.05)。结论贝前列素钠能显著降低早期糖尿病肾病的尿白蛋白/肌酐比值,改善血管内皮功能,且具有良好的安全性。Objective To observe the effect of baraprost sodium on urinary albumin-to-creatinine ratio （UACR） and vascular endothelial function in patients with early diabetic nephropathy. Methods Sixty-four cases with early diabetic nephropathy were randomly divided into two groups： control group was treated with 150 mg irbesartan, while treatment group with irbesartan and 40 μg baraprost sodium for three times per day. Before and after the treatment of 4 weeks, UACR, homocystetine（ Hcy）, endothelia （ ET-1 ） and nitric oxide （NO） were detected. Results After the treatment, the levels of UACR（ mg/ g） in the two groups significantly decreased （212 ± 121 vs 111 ±56 in treatment group and 214 ±125 vs 168±65 in control group respectively, P 〈 0.05 ） , and lower in treatment group than that in control group （ P 〈 0.05 ）. In treatment group Hcy and ET-1 significantly decreased, while NO significantly increased [ （ 1.91 ± 3.2） μmol/L vs （ 14.2 ± 2.6 ） μmol/L; （79.1 ±9.9） ng/L vs （45.2 ±9.2） ng/L; （ 47.6 ±8.5 ） μmol/L vs （ 89.0 ±9.4 ） μmol/L, P 〈 0.05 ） ], but no obvious changes in control group （ P 〉 0.05 ）. Conclusion Treatment of baraprost sodium could decrease the level of UACR, improve vascular endothelial function in patients with early diabetic nephropathy.

关 键 词：贝前列素钠 厄贝沙坦 糖尿病肾病 尿白蛋白 肌酐比值 血管内皮功能 

分 类 号：R587.2[医药卫生—内分泌]