不同剂量静脉注射人血免疫球蛋白治疗重症手足口病合并脑炎疗效分析  

Curative Effect Analysis of Different Doses of Intravenous Immunoglobin for Children With Severe Hand Foot and Mouth Disease Combined With Encephalitis

作　　者：于永锋[1] 初灵芝[1] 

机构地区：[1]山东省即墨市人民医院儿科,山东青岛266200

出　　处：《中华妇幼临床医学杂志（电子版）》2013年第2期184-186,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的探讨3种不同剂量静脉注射人血免疫球蛋白(IVIG)治疗重症手足口病(HFMD)合并脑炎的疗效。方法选择2012年6月至2012年9月于本院就诊的75例重症HFMD合并脑炎患儿为研究对象,并按照随机抽签法分为A组(n=25),B组(n=25)和C组(n=25)(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书)。3组患儿除均接受甘露醇、甲泼尼龙琥珀酸钠及对症支持治疗外,还分别接受不同剂量IVIG治疗,具体IVIG治疗方案:A组为1g/(kg·d)×2d,B组为500mg/(kg·d)×2d,C组为200mg/(kg·d)×2d。对3组患儿疗效进行比较。3组患儿年龄、病程、性别等比较,差异无统计学意义(P>0.05)。结果 A组与B组和C组患儿疗效比较,差异均有统计学意义(P1<0.05)。而B组和C组患儿疗效比较,差异无统计学意义(P2>0.05)。结论大剂量IVIG治疗重症HFMD合并脑炎,能迅速改善临床症状、缩短病程、阻止病情进展及降低危重并发症发生率,具有较好疗效。Objective To explore the curative effect of different doses of intravenous immunoglobin （IVIG） in children with severe hand foot and mouth disease（HFMD） combined with encephalitis. Methods From June to September 2012,75 children with severe HFMD combined with encephalitis were included in the study,and randomly divided into group A（n= 25）, group B（n= 25） and group C（n= 25）. Besides mannitol,methylprednisolone and other supportive treatments, different doses of IVIG were given in three groups respectively. The curative effect was compared among three groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of People＇s Hospital of Jimo. Informed consent was obtained from each parents. There was no significant difference in age, disease course and sex among three groups （P〉0.05）. Results There had significant differences in curative effect among three groups（P1 〈0.05）. There was no significant difference in curative effect between group B and group C （P2〉0.05）. Conclusions High-dose IVIG was effective to children with severe HFMD combined with encephalitis,it can relief the symptoms quikly, shorten the course of the disease, avoid the progress of the disease and decrease the incidence rate of complications.

关 键 词：静脉注射人血免疫球蛋白 剂量 手足口病 重症 脑炎 

分 类 号：R725.1[医药卫生—儿科]