头孢卡品的体外抗菌活性  

In vitro antimicrobial activity of cefcapene

作　　者：薛峰[1] 李耘[1] 吕媛[1] 吕健[2] 冯小龙[2] 刘健[1] 杨维维[1] 李曼宁[1] 

机构地区：[1]北京大学第一医院临床药理研究所,北京100034 [2]石药集团中奇制药技术(石家庄)有限公司,石家庄050051

出　　处：《中国临床药理学杂志》2013年第4期287-292,共6页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价头孢卡品体外抗菌活性。方法用琼脂二倍稀释法,测定头孢卡品对559株临床分离致病菌的最低抑菌浓度(MIC),并且比较各种试验条件改变后,对头孢卡品MIC值的影响。结果头孢卡品对甲氧西林敏感金黄色葡萄球菌(MSSA)和表皮葡萄球菌(MSSE)有很强的抗菌作用,MIC90分别为1,2mg.L-1。对大部分链球菌属细菌抗菌作用显著,对青霉素敏感肺炎球菌(PSSP)MIC90为1 mg.L-1。头孢卡品对ESBLs阴性大肠埃希菌和肺炎克雷伯菌的MIC90分别为1,2 mg.L-1。头孢卡品对流感嗜血杆菌和卡他莫拉菌具有显著的抗菌作用,对流感嗜血杆菌MIC值均小于0.03 mg.L-1。试验条件中,细菌接种量、培养基pH值及血清含量变化对头孢卡品MIC值基本无影响。结论头孢卡品体外抗菌活性,与头孢妥仑相似,优于头孢泊肟和头孢克肟。对β溶血性链球菌和流感嗜血杆菌抗菌作用显著。Objective To evaluate the in vitro antimicrobial activity of cefcapene against clinical isolates.Methods A total of 559 strains were included in this study.Minimal inhibitory concentrations（MIC） of antimicrobials were performed by the agar dilution method.Results Cefcapene had excellent antibacterial activity against both methicillin susceptive Staphylococcus and most Streptococcus spp.The MIC90 of cefcapene against methicillin susceptive S.aureus（MSSA） and S.epidermidis（MSSE） were 1 mg·L-1and 2 mg·L-1.The MIC90 of cefcapene against penicillin susceptive S.pneumoniae（PSSP） was 1 mg·L-1.The MIC90 of cefcapene against ESBLs negative Escherichia coli and Klebsiella pneumoiae were 1 mg·L-1and 2 mg·L-1,respectively.Cefcapene had good antibacterial activity against both Haemophilus influenzae and Moraxella catarrhalis,the MIC of cefcapene against Haemophilus influenzae less than 0.03 mg·L-1.The factors including inoculation quantity,pH value of medium and percentage of serum had no effect on MIC values.Conclusion Cefcapene exhibits good activity against most clinical strains in this study.The antibacterial activity of cefcapene were similar with cefditoren,and better than cefpodoxime and cefixime.The results of in vitro activity agree with other studies.

关 键 词：头孢卡品 体外抗菌活性 

分 类 号：R978.11[医药卫生—药品]