子痫前期孕妇血脂变化的临床意义  

Clinical significance of blood lipid changes in pregnant women with pre-eclamptic

作　　者：田立慧[1] 孙文翠 于德亮[1] 

机构地区：[1]海洋石油总医院体检中心,天津300450 [2]天津滨海新区塘沽妇幼保健院,天津300452

出　　处：《中国现代医学杂志》2013年第6期58-61,共4页China Journal of Modern Medicine

摘　　要：目的探讨子痫前期孕妇血脂变化的临床意义。方法随机选取150例正常孕妇,检测不同孕周的血脂水平并进行比较分析。选取82例子痫前期患者,分为轻度和重度两组,分别与正常孕晚期组比较血脂代谢变化。结果①正常孕妇的TG、TC、ApoA、ApoB、LDL-C水平随着孕周的增加呈上高趋势,组间差异有统计学意义(P<0.05);HDL-C水平变化无统计学意义(P>0.05);②PE组的TG、TC、ApoB、LDL-C水平均大于正常组,差异具有统计学意义(P<0.05);PE组的ApoA和HDL-C水平低于正常组,具有统计学差异(P<0.05);③MPE组与正常组相比,TG、TC、ApoB、LDL-C水平均增高,差异有统计学意义(P<0.05);ApoA与HDL-C无明显变化,无统计学差异(P>0.05)。SPE组与MPE组相比,TG、TC、ApoB、LDL-C水平均明显增高,差异有统计学意义(P<0.05);ApoA与HDL-C水平有所降低,有统计学差异(P<0.05)。结论 PE患者存在着明显的脂代谢异常,血脂水平与严重程度呈一定的线性趋势。因此,严格监测孕期血脂水平,对预防和改善子痫前期发病和疾病严重程度具有重要临床意义。【Objective】To investigate the clinical significance of blood lipid changes in pregnant women with pre-eclamptic.【Methods】150 cases of normal pregnant women were randomly selected,with detecting and analyzing the blood lipid levels of different gestational age.Another 82 patients of Pre-eclampsia were divided into MPE group and SPE group,their blood lipid levels were compared with normal third trimester of pregnant women.【Results】①The levels of TG,TC,ApoA,ApoB,LDL-C of normal pregnant women rised with increase of the gestational weeks,there was significant difference（P 0.05）.No significant in HDL-C levels（P 0.05）.②The levels of TG,TC,ApoB,LDL-C of PE group were higher than normal group,and the levels of ApoA and HDL-C were lower than normal group,both differences were statistically significant（P 0.05）.③Compared with normal group,MPE group having higher TG,TC,ApoB,LDL-C levels but having no significant change in ApoA and HDL-C levels;Compared with MPE group,SPE group having higher levels of TG,TC,ApoB,LDL-C（P） and lower levels of ApoA and HDLC,both differences were statistically significant（P 0.05）.【Conclusion】Pregnant women with pre-eclamptic exist obviously abnormal lipid metabolism,and lipid levels and the severity was a linear trend.So monitoring strictly of lipid levels during pregnancy has the important clinical significance in prevention and improvement of preeclampsia and the severity.

关 键 词：子痫前期 血脂水平 临床意义 

分 类 号：R714.2[医药卫生—妇产科学]