逆流色谱技术在手性分离中的研究进展  

Research progress on countercurrent chromatography in enantioseparations

作　　者：郑烨[1] 颜继忠[1] 童胜强[1] 

机构地区：[1]浙江工业大学药学院,杭州310032

出　　处：《药物分析杂志》2013年第4期536-543,共8页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金(21105090);浙江省自然科学基金(Y4100472);浙江省科技厅项目(2010C33144)资助

摘　　要：逆流色谱是一种良好的手性分离制备色谱技术,有着独特的拆分原理。本文首先介绍了逆流色谱手性分离原理,根据手性选择剂的分类及将逆流色谱作为手性反应器,综述了近年来逆流色谱在手性分离中的最新应用情况,总结了影响逆流色谱手性分离的影响因素,对如何提高逆流色谱手性分离能力作了探讨。Counter-current chromatography（CCC）is a preparative technique for chiral separation which has a unique chiral separation mechanism.In this paper,the chiral separation mechanism of CCC was introduced.Then the latest applications of counter-current chromatography in enantioseparations were reviewed on the basis of the classification of the chiral selector and counter-current chromatograph as the chiral reactor.The factors affecting the separation efficiency for chiral separation by counter-current chromatography were also summarized and the methods to improve the performance of CCC were discussed.

关 键 词：逆流色谱 手性分离 拆分原理 手性试剂 手性反应器 

分 类 号：R917[医药卫生—药物分析学]