夫妻双方HBV感染对IVF/ICSI治疗中胚胎发育及妊娠结局的影响  

Effects of hepatitis B virus infection in couples on the fetal growth and pregnancy outcomes of assisted reproductive techniques

作　　者：刘林丽[1] 单丹[1] 陈华[1] 吕杰强[1] 

机构地区：[1]温州医学院附属第二医院生殖医学中心,325000

出　　处：《实用医学杂志》2013年第8期1260-1262,共3页The Journal of Practical Medicine

摘　　要：目的:探讨夫妻双方均感染乙型肝炎病毒(HBV)对IVF/ICSI治疗中胚胎发育及妊娠结局的影响。方法:实验组为夫妇双方均乙肝表面抗原(HBsAg)阳性,对照组为夫妇双方均乙肝表面抗原(HBsAg)阴性。比较两组的正常受精率、卵裂率、优质胚胎率、着床率及临床妊娠率有无差异。结果:除优质胚胎率(58.61%比60.96%;P>0.05)外,HBV感染组正常受精率(77.11%比84.61%;P<0.05)、卵裂率(86.00%比98.23%;P<0.05)、着床率(11.11%比28.19%;P<0.05)及临床妊娠率(14.71%比37.25%;P<0.05)均较无HBV感染组显著降低,差异有统计学意义。结论:夫妻双方均为HBV感染者可能干扰了胚胎的发育,最终影响妊娠结局。Objective To investigate the effects of hepatitis B virus （HBV） infection in couples on the fetal growth and pregnancy outcomes of assisted reproductive technology. Methods 34 infertile couples, with positive hepatitis B surface antigen （HBsAg）, receiving IVF/ICSI-ET, were included as infection group. And 102 infertile couples, with negative HBsAg, receiving IVF/ICSI-ET were included as control group. The normal fertilization rate, cleavage rate, rate of good quality embryos, implantation rate, and clinical pregnancy rate were recorded and compared between the two groups. Results Except for high-grade embryo rate （58.61% vs. 60.96%, P 〉 0.05）, the normal fertilization rate, cleavage rate, implantation rate and clinical pregnancy rate in infection group were significantly lower than those in control group （77.11% vs. 84.61, 86.00% vs. 98.23%, 11.11% vs. 28.19%, 14.71% vs. 37.25%, all P 〈 0.05）. Conchmion HBV infection in couples could affect the outcomes of in vitro fertilization and embryo transfer treatment.

关 键 词：HBV感染 IVF ICSI 胚胎发育 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]