基于介孔二氧化硅纳米颗粒的可控释放体系  

Mesoporous Silica Nanoparticle-Based Controlled-Release System

作　　者：王文谦[1] 陈林峰[2] 温永强[1] 张学记[1] 宋延林[2] 江雷[2] 

机构地区：[1]北京科技大学化学与生物工程学院生物工程与传感技术研究中心,北京100083 [2]中国科学院化学研究所,北京100190

出　　处：《化学进展》2013年第5期677-691,共15页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21171019;21073203);教育部新世纪优秀人才支持计划(NCET-11-0584)资助

摘　　要：基于介孔二氧化硅的控制释放体系具有良好的生物相容性、细胞靶向性、精准响应性控制释放和到达目标位点前有效阻止药物释放等功能特性。近年来,基于介孔二氧化硅的可控释放体系已成为众多科研工作者研究的热点。本文讨论了基于介孔二氧化硅纳米颗粒可控释放体系的特点,同时以不同的响应特性为主线,系统分析和总结了各种响应性介孔二氧化硅控释体系的开关及其控制释放机制,包括氧化还原控释系统、光控释系统、pH控释系统及生物分子相关控释系统等一系列基于介孔二氧化硅的控释系统,并对该领域未来的发展方向作了展望。Mesoporous silica nanoparticles （MSNs）-based controlled-release system has the characteristics of good biocompatibility, cell targeting property, accurate responsive release, and eliminating undesirable drug release before reaching the target site, which has become a hot topic among many researchers in recent years. This article discussed the advantages of MSNs-based controlled-release system. Meanwhile, based on different stimuli- responsive characteristics, this article systematically analyzed and summarized various MSN-based controlled-release systems which was modified with different responsive switches, and further discussed the switching mechanisms of these devices, including redox-responsive controlled-release systems, light-responsive controlled-release systems, pH-responsive controlled-release systems and biological molecule-responsive controlled-release systems. The prospects and directions of this research field are also briefly addressed.

关 键 词：可控释放 介孔材料 界面材料 功能化 响应性开关 智能材料 

分 类 号：O647.32[理学—物理化学] TB381[理学—化学]