温度敏感性药物载体及其在肿瘤热化疗中的应用  

Thermo-Sensitive Drug Delivery and Relevant Applications on Thermo-Chemotherapy

作　　者：屈阳[1] 李建波[1,2] 任杰[1,3] 

机构地区：[1]同济大学材料科学与工程学院纳米与生物高分子材料研究所,上海201804 [2]同济大学化学系,上海200092 [3]同济大学先进土木工程材料教育部重点实验室,上海201804

出　　处：《化学进展》2013年第5期785-798,共14页Progress in Chemistry

基　　金：国家科技支撑计划课题(No.2012BAI15B06);上海市科学技术委员会纳米技术专项(No.11nm0505100);中国博士后科学基金项目(No.2012M510116);中央高校基本科研业务费专项资金项目(No.0500219160)资助

摘　　要：温度敏感性材料由于其理化性质对温度变化高度敏感,同时相变温度又易于调控,因而成为条件响应型药物控释载体中的研究热点。多种类型的温敏性药物载体,包括脂质体、聚合物囊泡、聚合物胶束,经过多年的研究和优化,其稳定性得到进一步的提高,而相变温度也实现了在较宽范围内的随意调整,可同时适用于病理性的高热和局部人工热疗等多种方式的温敏靶向性释药。并且,由于局部热疗可以有效控制温敏载体的药物释放,同时,热疗还能有效增强化疗药物的细胞毒性,因此温敏药物载体在肿瘤化疗和热化疗领域具有独特的应用潜力。本综述简要回顾了温敏性载体在药物载体领域的研究现状。在此基础上,从对肿瘤热化疗原理、发展现状、疗效影响因素的角度,进一步综述了温敏性药物载体在肿瘤热化疗领域的研究进展,特别关注了复合型温敏载体,因为这类载体结合了具有光热/磁热效应的纳米颗粒而兼具自升温能力,因而在靶向性热化疗中独具优势。最后,本文结合热化疗的影响因素,对温敏性载体在肿瘤热化疗领域的发展方向进行了展望。Due to the effectiveness of hyperthermia on significant enhancement of drug cytotoxieity, thermo- chemotherapy has become an extraordinarily encouraging approach to optimize cancer therapy by combing hyperthermia and chemotherapy. Moreover, a great number of in vitro/vivo researches and random clinic trials have confirmed its effectiveness, which is affected greatly by thermal dose. Meanwhile, hyperthermia is also a critical factor on triggering drug release of thermal-sensitive drug delivery. Accordingly, it is an optimal design that thermal-sensitive drug carriers integrate with local hyperthermia to realize the targeted thermo-chemotherapy. Therefore, the thermal-sensitive drug carriers displayed a unique potential and applied prospection on targetedthermo-chemotherapy, which contributed to increasing drug concentration, enhancing drug cytotoxicity, lowering effective dose and alleviating side effects further. In this review, the research situation of thermal-sensitive drug carriers on chemotherapy and its advantage on thermo-chemotherapy were summarized briefly as the applied background. In addition, the biological rationales and research situation of thermo-chemotherapy were expounded. Based on aforementioned researches, the review focused on the research situation of the thermal-sensitive drug delivery on thermo-chemotherapy. Furthermore, the review highlighted the composite thermal-sensitive carriers containing functional photothermal/magnetocaloric nanoparticles, because their self-heating and self-imaging can be untilized for precise targeting and monitoring. Finally, the review analyzed and stressed the relahionship between properties of thermal-sensitive nanocarriers and optimal TER temperature, and pointed out development tendency of composite thermal-sensitive carriers on thermal-chemotherapy.

关 键 词：温度敏感性药物载体 光热效应 磁热效应 热化疗 

分 类 号：O631.1[理学—高分子化学] R318.08[理学—化学]