桦褐孔菌甲醇提取物抗氧化及抗炎作用研究  

The antioxidant and anti-inflammatory effects of the Inonotus obliquus methanol extract

作　　者：潘桂玲[1] 韩强[1] 

机构地区：[1]江苏省徐州医学院附属医院药剂科,徐州221002

出　　处：《北方药学》2013年第4期59-60,共2页Journal of North Pharmacy

摘　　要：目的:观察桦褐孔菌甲醇提取物的抗氧化及抗炎作用,为更合理有效地开发该多糖真菌提供科学依据。方法:通过大鼠足肿胀及大鼠棉球肉芽组织增生模型考察其抗炎活性,并通过清除DPPH自由基活性的清除作用评价其抗氧化作用。结果:100mg/kg以上的桦褐孔菌甲醇提物对角叉菜胶所致大鼠足肿、大鼠棉球肉芽组织增生有抑制作用;100mg/kg的桦褐孔菌甲醇提物可以清除DPPH自由基。结论:桦褐孔菌甲醇提取物具有良好的抗氧化及抗炎作用。Objective：To observe the antioxidant and anti-inflammatory effects of Inonotus obliquus methanol extract,to provide a scientific basis for a more rational and effective development of the polysaccharide fungi. Methods：Use rats foot swelling and cotton ball granulation tissue formation model to observed its anti-inflammatory activity,and to evaluate its antioxidant role by clearing the scavenging effect of DPPH radical activity. Results：The experimental results show that the the Inonotus obliquus over 100mg/kg methanol extract of carrageenan-induced rat paw edema inhibition in rats tampon granulation tissue; 100mg/kg Inonotus obliquus methanol extract DPPH radical scavenging. Conclusion：The Inonotus obliquus methanol extract has antioxidant and anti-inflammatory effects.

关 键 词：桦褐孔菌 抗炎 抗氧化 

分 类 号：R284[医药卫生—中药学]