酸枣仁汤拆方后成分变化的研究  

Study on Components Change after Taking Apart Suanzaoren Decoction

作　　者：孙志翠[1] 裴强伟[1] 韩涛[1] 王欣[1] 

机构地区：[1]山东中医药大学基础医学院,山东济南250355

出　　处：《辽宁中医杂志》2013年第4期761-763,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：山东省优秀中青年科学家科研奖励基金(BS2011YY054)

摘　　要：目的:建立酸枣仁汤、各单味药及拆方组水煎液高效液相(HPLC)指纹图谱,研究酸枣仁汤拆方后成分变化,为酸枣仁汤药效物质基础及配伍规律研究提供方法学依据。方法:制备酸枣仁汤、各单味药及拆方组供试液,相同色谱条件下建立其指纹图谱,将各色谱图进行对比分析,对色谱峰进行归属及定量分析。结果:在酸枣仁汤指纹图谱中共检出23个成分,拆方组成分均有一定减少,且相对单味药共有成分含量有明显变化。结论:单味药与诸药合煎成分及含量存在显著差异,且本研究建立的方法准确、可靠、重现性好,可用于酸枣仁汤药效物质基础及配伍规律的研究。Objective：To establish the high performance liquid（HPLC） fingerprint of Suanzaoren Decoction （SZRD） as well as each single drug and taking apart ones, and to research components change after taking apart SZRD, providing methodological basis for the research on efficacy material base and compatibility law of SZRD. Methods ： Liquid of SZRD, each single drug and taking apart ones was prepared for establishing their fingerprints with the same chromatographic conditions, contrasting each chromato- graphic graphs and analysing each chromatographic peak. Results ：23 components in fingerprint of SZRD were detected, and some components in taking apart ones were reduced, and contents of common composition were obviously different comparing with single drug. Conclusion ： There are obviously difference of components and contenst between single drug and SZRD, and the method established in the research is accurate and reliable with good reproducibility, and it can be used for the research on efficacy material base and the compatibility laws of SZRD.

关 键 词：酸枣仁汤 拆方 成分变化 配伍规律 药效物质基础 

分 类 号：R284[医药卫生—中药学]