广东省成人血脂异常患病率及其危险因素的相关性研究  

Association study of prevalence of dyslipidemia and its risk factors among adults in Guangdong Province

作　　者：莫景富[1] 宋秀玲[2] 许燕君[2] 许晓君[2] 何群[2] 蔡秋茂[2] 徐浩锋[2] 夏亮[2] 

机构地区：[1]汕头大学医学院公共卫生硕士教育中心,广东汕头515041 [2]广东省疾病预防控制中心

出　　处：《华南预防医学》2013年第2期11-17,共7页South China Journal of Preventive Medicine

摘　　要：目的了解广东省18岁及以上人群血脂异常患病率及其危险因素,为制定相应干预策略提供科学依据。方法采用多阶段分层随机整群抽样方法于2010年抽取广东省6个监测县(区、市)18岁及以上居民进行问卷调查(人口统计学资料、吸烟、喝酒、饮食和体力活动等)、体格检查(体重、身高和血压的测量)及血生化检测(甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇和血糖的检测),采用单因素、多因素非条件logistic回归分析血脂异常的危险因素。结果共调查3 577人,其中男性1 615人,平均年龄(50.28±14.05)岁,女性1 962人,平均年龄(49.21±13.51)岁。广东省18岁及以上人群血脂异常总患病率为60.7%(2 173/3 577),标化率为56.0%。男女性患病率分别为68.9%(1 113/1 615)和54.0%(1 060/1 962),男性高于女性(P<0.01)。城市和农村居民患病率分别为61.0%(1 088/1 785)和60.5%(1 085/1 792),城乡差异无统计学意义(P>0.05)。其中高胆固醇血症患病率为2.5%(标化率4.1%),混合型高脂血症患病率为1.9%(标化率3.3%),高甘油三酯血症患病率为4.5%(标化率5.0%),低高密度脂蛋白胆固醇血症患病率为57.3%(标化率49.9%)。多因素非条件logistic回归分析结果表明,超重(OR=1.554)、肥胖(OR=2.321)、腹部肥胖(OR=1.300)、吸烟(轻度、中度和重度吸烟OR值分别为2.189、2.042和1.874)和蔬菜摄入量<300 g/d(OR=1.389)是影响广东省18岁及以上人群血脂异常的危险因素,体质偏轻(OR=0.539)、身体活动活跃(OR=0.601)和身体活动充分(OR=O.658)是广东省18岁及以上人群血脂异常的保护因素。结论广东省18岁及以上人群血脂异常患病率已经达到较高水平,血脂异常以低高密度脂蛋白胆固醇血症和高甘油三酯血症为主,建议加强血脂异常的综合防治力度。Objective To explore the prevalence and related risk factors of dyslipidemia among a- dults in Guangdong Province, and to provide evidence for prevention and intervention of dyslipidemia. Methods Inhabitants aged 18 years and over were chosen by using multi-stage stratified cluster sampling method from 6 counties in Guangdong Province in 2010. Questionnaire survey （demographics, smoking, drinking, diet, physical activity, etc. ） , medical examination （measurement of weight, height, and blood pressure）, and biochemical detection [ triglycerides, low density lipoprotein cholesterol （LDL-C） , high density lipoprotein cholesterol （HDL-C）, total cholesterol （TC） and blood sugar] were conducted among the residents. Models of the univariate and multivariate non-conditional logistic regressions were used to an- alyze the risk factors of dyslipidemia. Results A total of 3 577 people were surveyed. Of them, 1 615 were males （ average age 50.28 ± 14. 05 years） and 1 962 females （ average age 49.21 ± 13.51 years）.The overall prevalence of dyslipidemia was 60. 7% （ 2 173/3 577 ） , the standardized prevalence rate was 56.0%. The prevalence rates in men （68.9% , 1 113/1 615） was higher than that in women （54.0%, 1060/1 962） （P 〈0. 01 ）. The prevalences in urban and rural populations were 61.0% （ 1 088/1 785 ） and 60. 5 % （ 1 085/1 792） （P 〉 0.05 ）. The prevalences of isolated hypercholesterolemia, mixed hyperlip- idemia （ elevated TC and triglycerides）, isolated hypertriglyceridemia and isolated low HDL-C were 2. 5% （standardized prevalence rate 4. 1% ） , 1.9% （standardized prevalence rate 3.3% ） , 4. 5% （standardized prevalence rate 5.0% ） and 57.3% （ standardized prevalence rate 49.9% ）, respectively. Multivariate lo- gistic regression analysis showed that overweight （ OR = 1. 554）, obesity （ OR = 2. 321 ）, central obesity （ OR = 1. 300 ） , smoking [ the mild smoking group （ OR = 2. 189 ） , moderate smoking group （ OR = 2. 042

关 键 词：高血脂症 高胆固醇血症 高甘油三酯血症 低高密度脂蛋白胆固醇血症 混合型高脂血症 

分 类 号：R55[医药卫生—血液循环系统疾病]