基于残基接触数的蛋白质折叠速率预测  

Prediction of Protein Folding-rate Based on the Residues Contact Number

作　　者：胡睿[1] 史小红[1] 

机构地区：[1]西安工业大学理学院,西安710021

出　　处：《西安工业大学学报》2013年第2期146-150,共5页Journal of Xi’an Technological University

基　　金：陕西省教育厅专项科研计划项目(2010JK596)

摘　　要：文中从蛋白质的三级结构出发,对数据集中二态和多态蛋白质的接触数进行筛选分类,建立了一个利用蛋白质残基接触数来预测蛋白质折叠速率的线性回归模型.模型计算预测的折叠速率和实验验证的折叠速率的相关系数以Cα原子为特征时达到了0.832,以N原子为特征时达到了0.903.结果表明残基间的相互作用对蛋白质折叠速率有很大的影响;蛋白质残基中的N原子与其他原子的相互作用对折叠速率的影响要大于残基中Cα原子对折叠速率的影响.Based on the tertiary structure of protein, contact number categories from a database of two and multi--state proteins is created. A linear regression model is built for predicting the protein folding rate using protein contact number. The correlation between predicted folding rates and experimental folding rates is 0. 832 with C. atom as characteristic. With N atom as characteristic, the correlation with folding rates reaches 0. 903. It is proved that the residues interactions in a protein are an important determinant of the protein folding rate. The interaction effect of N atom and other atoms on the folding rate is superior to the interaction effect of C. atom and other atoms.

关 键 词：蛋白质折叠 折叠速率 接触数 回归分析 

分 类 号：Q51[生物学—生物化学]