山莨菪碱在大鼠急性全脑缺血再灌注损伤中对一氧化氮内皮素-1及能量代谢的影响  

Influence of anisodamage on NO、ET-1 and energy metabolism after acute brain damage following complete cerbral ischemia- reperfusion in the rats

作　　者：汤彦[1] 杨光田[1] 蒋崇慧[1] 汪培华[1] 邓普珍[1] 

机构地区：[1]同济医科大学附属同济医院急诊科,湖北武汉430030

出　　处：《中国急救医学》2000年第4期201-203,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的　了解山莨菪碱在大鼠急性全脑缺血再灌注损伤中对一氧化氮（ＮＯ）、内皮素－１（ＥＴ－１）、ＡＴＰ及乳酸的影响，探讨山莨菪碱（Ａｎｉ）对脑缺血再灌注损伤的保护作用。方法采用Ｒｕｌｓｉｎｅｌｌｉ方法建立大鼠急性全脑缺血再灌注损伤模型。观察Ａｎｉ在再灌注期间对ＮＯ、ＥＴ－１及能量代谢的影响。结果Ａｎｉ可以抑制再灌注早期（１小时组）ＮＯ、ＥＴ－１及乳酸的过量产生，提高脑组织ＡＴＰ含量。结论　Ａｎｉ可以通过对ＮＯ、ＥＴ－１及能量代谢的影响对脑起保护作用。Objective To find the influence of anisodamine (Ani) on NO, ET - 1, ATP and Lactate in the brain tissues after the global ischemia- reperfusion of rats and the protective effects of Ani were also observed.Methods The four-vessel occlusion models was made as discribed by Pulsinelli-Brier- ley in Sprague- Daewley rats. Observing the influence of Ani on NO,ET - 1 and energy metabolism during the reperfusion period. Result Ani can depress the marked increase of NO, ET - 1 and Lactate in the early stage of reperfusion,and also improve the contents of ATP. Conclusions Ani have a remarkble protec- tion on cerebral ischemia - reperfusion damage. Its mechanisms may be involoved in the influence of Ani on NO, ET - 1 and energy metabolosm.

关 键 词：再灌注损伤 全脑缺血 山莨菪碱 NO EF1 

分 类 号：R96[医药卫生—药理学]