新疆南疆地区371株分枝杆菌耐药状况分析  

Analysis of the 371 drug-resistance of tuberculosis strings from the southern regions of Xinjiang

作　　者：闫雪梅[1] 张琼[1] 张朝霞[1] 

机构地区：[1]新疆医科大学第一附属医院医学检验中心,新疆乌鲁木齐830011

出　　处：《中国实验诊断学》2013年第4期688-691,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的了解新疆南疆地区结核病患者的耐药状况,为耐药结核病防治提供参考依据。方法收集2010年5月至2011年5月新疆南疆地区结核病患者痰液标本,进行结核分枝杆菌的分离培养及菌种初步鉴定,应用比例法对分离菌株进行8种抗结核药物(异烟肼、利福平、链霉素、乙胺丁醇、卷曲霉素、卡那霉素、阿米卡星、氧氟沙星)的耐药性监测。结果共纳入分枝杆菌371株,总耐药率32.1%,初治耐药率30.3%,复治耐药率33.2%。总耐药顺位为异烟肼>利福平>链霉素>乙胺丁醇>卷曲霉素>卡那霉素>氧氟沙星>阿米卡星。结论新疆南疆地区结核病耐药严重,应采取有效的防控措施。Objective To analyze drug-resistance of tuberculosis from the southern regions of Xinjiang,and provide the evidence for the control and prevention. Methods Sputum samples from patients with TB were collected from the southern regions of Xinjiang from May 2010 to May 2011. The cultivation , and preliminary identification of MTB were done. The proportion method was used for testing the strains＇ susceptibility to 8 anti-tuberculosis drugs （isoniazid,rif- ampicin, streptomycin, ethambuol, capreomycin, kanamycin, amikacin, ofloxacin）, and then analysis the results. Results 371 strains were included the prevalence of overall resistance among all cases was 32. l%,the drug-resistance rate of the new cases was 30.3% ,and the re-treatment cases was 33.2%. The sequence of the drug resistance was isoniazid〉 rifampicin〉streptomycin〉 ethambuol〉 capreomycin〉 kanamycin〉ofloxacin〉 amikacin. Conclusion The status of drug resistance tuberculosis in this area is serious, implement the strategies and strengthen surveillance seriously to pre- vent against drug-resistance tuberculosis.

关 键 词：结核病 耐药 耐多药 

分 类 号：R446.5[医药卫生—诊断学]