代谢综合征与大肠肿瘤的相关性研究  

Study on the Correlation of Metabolic Syndrome and the Incidence of Colorectal Neoplasms

作　　者：吴礼浩[1] 谢文瑞[1] 陈羽[1] 马伟钦[1] 张伟斌[2] 何兴祥[1] 

机构地区：[1]广东药学院附属第一医院消化内科,广东广州510080 [2]广东药学院附属第一医院胃肠外科,广东广州510080

出　　处：《湖北民族学院学报（医学版）》2013年第1期1-4,共4页Journal of Hubei Minzu University(Medical Edition)

基　　金：国家自然科学基金青年基金(61201437);广东省医学科研基金(A2011315)

摘　　要：目的探讨代谢综合征与大肠肿瘤的关系。方法选取2010年1月1日～2011年4月1日在我院住院行肠镜检查者为研究对象,按病理活检结果分为正常组、大肠腺瘤组、大肠癌组。检测各组空腹血糖(FPG)、血脂及其分型,空腹胰岛素(FINS)水平;测量血压以及身高、体质量、腰围、臀围等人体生理学指标;记录其性别、年龄、吸烟、饮酒等资料。代谢综合征与大肠肿瘤的相关性分析用logistic回归方法和秩相关分析。结果代谢综合征是大肠癌的危险因素;胰岛素抵抗指数(RI)与大肠癌呈正相关,年龄≥50岁、男性、血apoA减低是大肠癌的危险因素。女性患代谢综合征是大肠腺瘤的危险因素;年龄≥50岁、血apoB增高是大肠腺瘤的危险因素。结论代谢综合征与大肠肿瘤密切相关。Objective To study the correlation of metabolic syndrome and incidence of colorectal neoplasm.Methods All cases in hospital receiving colonoscopy from Jan. 1,2010 to April 1 ,2011 were analyzed and divided into normal group,colorectal adenoma group and colorectal carcino- ma group. FPG, blood lipid and FINS were detected in addition to blood pressure, height, weight, waist, hip circumferences in all cases. Recode was kept of the age, gender, history of smoking, drinking alcohol etc. Logistic regression analysis and Spearman rate correlation were used to analyze the correlation of metabolic syndrome and colorectal adenoma.Results Metabol- ic syndrome was a risk factor for colorectal cancer, insulin resistance index was positively as- sociated with the incidence of colorectal cancer; Age ≥50 years old, male, decreased apoA were risk factors for colorectal cancer; Female with Metabolic syndrome was a risk factor for colorectal adenoma; Age≥50 years old, elevated apoB were risk factors for colorectal adeno- ma. Conclusion Metabolic syndrome was closely associated with colorectal neoplasm.

关 键 词：结直肠肿瘤 代谢综合征 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌] R735.34[医药卫生—内科学]