健康和疾病的发育起源  

Health and developmental origins of disease

作　　者：李君[1] 李婷[1] 

机构地区：[1]同济大学附属第一妇婴保健院,上海200040

出　　处：《上海医药》2013年第6期16-20,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：20世纪90年代,基于临床流行病学的一些发现,英国学者David Barker教授最早提出健康和疾病的发育起源这一概念。目前发现,几乎所有的成人慢性疾病,例如代谢性疾病、心血管疾病、肿瘤等都与发育早期的环境有关。这个假说得到了大量临床流行病学和动物实验等基础研究的证实。它的意义在于,在临床上,有这样一个"窗口期",通过合理的规范孕妇的营养和行为,以及合理的出生后早期营养,能够避免胎儿和婴儿暴露于不良的环境中,从而降低他们成年后发生慢性疾病的风险。因此健康和疾病的发育起源这一概念有现实的临床意义。Based on some findings of clinical epidemiology, the British professor David Barker proposed the concept of the developmental origins of health and disease （DOHaD） in the 1990s. Almost all the chronic diseases, such as metabolicdiseases, cardiovascular diseases, cancers, are proved to be related with the early stage of development. DOHaD has been verified by the clinical epidemiological researches and animal experiments. It is important to know that we have a ＂window＂ in the early stage, in which, if we care the pregnant women or new babies carefully to avoid them from harmful environment, we can reduced the morbidity of adult chronic disease of these babies when they grow up. Therefore, DOHaD has a clinical significance.

关 键 词：健康和疾病 发育起源 孕产妇 

分 类 号：R714.2[医药卫生—妇产科学]