衍生还原裂解法研究木质素类药物的结构  

Molecular Structure of Lignin Pharmaceutical Samples by Reductive Cleavage

作　　者：张静[1] 徐鸽[1] 于大钢 吴国平 陈和新 

机构地区：[1]常州大学石油化工学院,江苏常州213164 [2]江苏健民制药有限公司,江苏常州213018

出　　处：《林产化学与工业》2013年第2期71-76,共6页Chemistry and Industry of Forest Products

基　　金：常州市社会发展计划资助项目(CS20092011);常州大学校基金资助项目(ZMF1202043)

摘　　要：采用衍生还原裂解法(DFRC)对木质素类药物进行降解,并且采用GC-MS分析裂解产物的组成和结构。结果显示:木质素类药物降解产物中包含有4类化合物,即2,6-二叔丁基-4-甲基苯酚(BHT),单糖,有机酸和相关木质素单元。在1#药物和2#药物中上述4种化合物分别为:12.696%、17.456%、17.989%和51.859%;8.736%、2.991%、44.812%和43.461%。根据所得到的木质素类药物降解产物的生物活性,推测木质素类药物的药效作用可能是由于木质素类药物在人体内能分解为BHT、阿魏酸和甘油单元结构所致。在1#药物和2#药物中,可能在人体内转化为阿魏酸的化合物总量分别为12.572%和5.613%;含有甘油单元的化合物总量分别为6.322%和25.430%。Degradation of lignin pharmaceutical by derivatization followed by reductive cleavage （DFRC） was studied. The compositions and structures of degraded products were analyzed by GC - MS. The results showed that the degraded products from lignin pharmaceutical consisted of four types of compound, i. e. , butylated hydroxyltoluene （BHT）, monose, organic acid and related lignin units. In 1^# and 2^# pharmaceutical, the content of previous four kinds compounds was 12. 696 %, 17.456 %, 17. 989 % and 51. 859 % ; 8. 736 %, 2. 991% , 44. 812 % and 43. 461% , respectively. According to the biological activity of degraded products obtained by lignin pharmaceutical, the drug actions presumed could be due to the decomposition of lignin phar- maceutical in the human to BHT, ferulic acid and glycerine units. In 1^# and 2^# pharmaceutical, the content of total compounds converted into ferulic acid in the body was 12. 572 % and 5. 613 %. Furthermore, the content of total containing glycerine units compounds was 6. 322 % and 25. 430 %, respectively.

关 键 词：衍生还原裂解法 木质素 药物 GC-MS 

分 类 号：TQ35[化学工程] TS721.2[轻工技术与工程—制浆造纸工程]