微波法合成酪醇衍生物及其抗氧化作用研究  

Microwave-assisted Synthesis of Tyrosol Derivatives and the Antioxidation

作　　者：李玉民[1] 张新颜[2] 祝辉[2] 李运明[2] 杨涛[2] 

机构地区：[1]成都军区联勤部成都药材供应站,成都610017 [2]成都军区总医院,成都610083

出　　处：《西南军医》2013年第3期262-264,共3页Journal of Military Surgeon in Southwest China

基　　金：成都军区医学科研计划课题（MB09041）

摘　　要：目的设计、合成具有抗氧化、清除自由基作用的新型酪醇衍生物。方法以具有抗氧化作用的酪醇为先导结构,经结构修饰引入查尔酮结构单元增强其抗氧化、清除自由基作用。采用DPPH和FRAP法测定其体外抗氧化、清除自由基作用。结果采用微波合成反应,经邻位乙酰化、Claisen–Schmidt缩合以及水解3步反应高效制备了一系列含查尔酮结构单元的新型酪醇衍生物,所有化合物体外抗氧化、清除自由基活性均强于酪醇对照品。结论设计、合成并筛选可以得到一类新型酪醇衍生物。Objective To design and synthesize novel tyrosol derivatives with the effect of antioxidation and free radical scavenging. Methods Based on the temple structure of p-tyrosol, a small library of salidroside derivatives containing chalcone substructural unit were synthesized and evaluated for their anti-oxidant activities by DPPH and FRAP methods. Results The novel tyrosol derivatives were prepared from p-tyrosol through ortho acetylation, subsequently claisen - schmidt condensation and hydrolytic decomposition un- der microwave-assisted conditions; DPPH and FRAP assay demonstrated that all the compounds showed improved free radical scavenging activity and antioxidant power when comparing to the reference p-tyrosol. Conclusions A novel series of tyrosol derivatives were designed and synthesized.

关 键 词：红景天苷 合成 微波反应 抗氧化 

分 类 号：R961[医药卫生—药理学]