普通干扰素和长效干扰素治疗慢性乙型病毒性肝炎的疗效对比  

Comparison of Effects between Ordinary Interferon and Peginterferon for Treating Chronic Viral Hepatitis B

作　　者：陈毅芳[1] 张玮[1] 裘琳琳[1] 王鼎盛[1] 何兰香[1] 胡峰明[1] 

机构地区：[1]浙江省杭州市余杭区第一人民医院药剂科,浙江杭州311100

出　　处：《中国药业》2013年第7期94-95,共2页China Pharmaceuticals

摘　　要：目的比较普通干扰素和长效干扰素治疗慢性乙型病毒性肝炎的疗效。方法选取2011年1月至2012年12月的150例慢性乙型病毒性肝炎患者作为研究对象,随机平均分为两组,治疗组75例给予长效干扰素治疗,对照组75例应用普通干扰素治疗,记录和比较两组患者肝功能及病毒学指标。结果治疗24和48周后,治疗组丙氨酸氨基转移酶(ALT)复常率、乙型肝炎病毒(HBV)-DNA转阴率、HBeAg阴转率、HBeAg抗HBe血清转换率、HBsAg阴转率均显著高于相应时期的对照组(P<0.05),且并未发生严重的不良反应。结论长效干扰素较普通干扰素治疗慢性乙型肝炎的效果更理想。Objective To compare the effects between ordinary interferon and peginterferon in the treatment of chronic viral hepatitis B. Methods A hundred and fifty patients with chronic viral hepatitis B from January 2011 to December 2012 were selected as the research subjects and divided into the two groups randomly and equally. The treatment group（75 cases） was given the long-acting interferon therapy and the control group（75 cases） received the ordinary interferon therapy. Then, the liver function and virological indicators were recorded and compared between the two groups. Results After 24- week and 48-week treatment, ALT normalization, HBV DNA sero- conversion rate, HBeAg seroconversion rate, HBeAg anti- HBe seroconversion and HBsAg seroconversion in the treatment group were all significantly higher than those in the corresponding period of the control group （P 〈0. 05）. No serious adverse events occurred. Conclusion The effect of peginterferon for treating chronic viral hepatitis B is more ideal than the ordinary interferon.

关 键 词：普通干扰素 长效干扰素 慢性乙型病毒性肝炎 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]