二羟基乙二肟的合成与晶体结构  

Synthesis and crystal structure of dihydroxglyxime

作　　者：张俊娜[1] 何炜[1] 兰婷[1] 李明华[1] 王宝龙[1] 

机构地区：[1]第四军医大学药学系,陕西西安710032

出　　处：《应用化工》2013年第4期771-773,共3页Applied Chemical Industry

摘　　要：以盐酸羟胺和草酸二乙酯为原料,在乙醇-水溶液中反应,得到二羟基乙二肟(DHG),培养出该化合物的单晶。并利用元素分析、红外光谱、X射线单晶衍射等方法对该化合物进行了表征。结果表明,该晶体属于单斜晶系,空间群为Pn,晶胞参数a=0.522 19(15)nm,b=0.387 37(11)nm,c=1.075 0(3)nm,β=115.396(5)°,V=0.216(11)nm3,Dc=1.873 g/cm3,Z=2,F(000)=128,R1=0.029 8,wR2=0.079 0。The compound of dihydroxglyxime （DHG） was prepared by reaction of hydroxylamine hydro- chloride with diethyl oxalate in ethanol aqueous solution, single crystal of DHG was obtained. The molecular structure was characterized by elemental analysis, IR and sfngle X-ray diffraction analysis. The results show that the crystal belongs to a monoclinie system with Pn space group and dell parameters of a = 0.522 19（15） nm,b =0.387 37（11） nm,c =1.075 0（3） nm,β=115.396（5）°,V=0.216（11） nm3, Dc =1.873 g/cm3,Z =2,F（000） = 128,RI =0.029 8,wR2 =0.079 0.

关 键 词：二羟基乙二肟 盐酸羟胺 草酸二乙酯 晶体结构 

分 类 号：TQ463.5[化学工程—制药化工]