4-羟基-3-异丁基苯硼酸的合成研究  

Research on the synthesis of 4-hydroxy-3-isobutylphenylboronic acid

作　　者：陈建军[1] 周丽萍[1] 

机构地区：[1]台州职业技术学院生物与化工学院,浙江台州318000

出　　处：《应用化工》2013年第4期774-776,共3页Applied Chemical Industry

摘　　要：以5-溴-2-羟基苯甲醛(2)为起始原料,经苄基保护,与Wittig试剂反应,得关键中间体(4),(4)经格氏、酯化及水解反应,得4-苄氧基-3-异丁烯基苯硼酸(5),(5)经氢化还原反应,制得4-羟基-3-异丁基苯硼酸(1),总产率为63%。关键的中间体及产物的结构通过1H NMR、13C NMR和MS表征确认。The route was started with 5-bromo-2-hydroxybenzaldehyde （2）, which was converted into the corresponding （4） by benzylation, followed by the reaction with Wittig reagent. 4-Benzyloxy-3-isobutenylphenylboronic acid（5 ）as synthesized by a three-step reaction of Grignard reaction and esterification and hydrolysis from （4）. The title compound （1） in overall yield of 63% was synthesized by the hydrogenation reduction reaction of （5）, and the structures of related intermediates and the product were characterized by 1H NMR,13C NMR and MS spectra.

关 键 词：4-羟基-3-异丁基苯硼酸 FRIEDEL-CRAFTS反应 Wittig试剂 格氏试剂 合成 

分 类 号：TQ460.6[化学工程—制药化工]