特殊模式HBsAg、HBsAb双阳性患者部分临床指标分析  

alysis on HBsAg and HBsAb double positive patients whose part of the clinical indexes

作　　者：崔洁[1] 席向红[1] 张建荣[1] 

机构地区：[1]宁夏医科大学总医院医学实验中心,宁夏银川750004

出　　处：《宁夏医学杂志》2013年第4期319-320,共2页Ningxia Medical Journal

摘　　要：目的研究乙肝特殊模式HBsAg、HBsAb双阳性患者外周血中HBV-DNA载量及肝功能指标,及其在不同性别、年龄群体中的差异,为HBsAg、HBsAb双阳性患者的治疗提供一定帮助。方法收集155例HBsAg、HBsAb双阳性患者及30例乙肝"大三阳"患者,检测其外周血中HBV-DNA载量及肝功能指标。结果 155例HBsAg、HBsAb双阳性患者外周血中HBV-DNA载量在不同性别组及不同年龄组中差异无统计学意义(P>0.05);HBsAg、HBsAb双阳性患者与乙肝"大三阳"患者外周血中HBV-DNA载量差异有统计学意义(P<0.05);HBsAg、HBsAb双阳性患者与乙肝"大三阳"患者外周血中ALT(丙氨酸氨基转移酶)、AST(门冬氨酸氨基转移酶)含量差异无统计学意义(P>0.05)。结论乙肝特殊模式HBsAg、HBsAb双阳性患者外周血中HBV-DNA载量与乙肝"大三阳"患者差异有统计学意义,较之减少,可为双阳性患者的个性化治疗提供一定临床帮助。Objective To study the rare mode-HBsAg and HBsAb double positive patients whose HBV -DNA loaded in pe-ripheral blood and liver function index, gave a hand for the patients with HBsAg and HBsAb double positive in clinical treatment. Methods 155 cases with HBsAg and HBsAb double positive chronic hepatitis B patients and 30 cases of hepatitis B patients with HB-sag, HBcAb and HBeAg all positive, the difference between the two groups was HBV - DNA load and liver function index. Results 155 cases of HBsAg and HBsAb double positive patients whose HBV - DNA load was no statistical difference in different gen-der groups and different age group （P =0. 180 and 0. 844）, the HBV -DNA load was different in HBsAg and HBsAb double positive group and HBsAg, HBcAb and HBeAg all positive group （P = 0.05）. There was no statistical difference with ALT and AST in two group （P = 0.739 and 0.795）. Conclusion Hepatitis B rare mode, HBsAg and HBsAb double positive patients whose HBV - DNA load in peripheral blood has statistically significant with HBsAg, HBcAb and HBeAg all positive group, is decreased than HBsAg, HB-cab and HBeAg all positive group, the conclusion can provide personalized treatments for the double positive patients.

关 键 词：乙型肝炎 乙肝表面抗原 乙肝表面抗体双阳性 乙型肝炎“大三阳” 乙肝病毒核酸 肝功能 

分 类 号：R512.62[医药卫生—内科学]