GRP78蛋白在肝癌组织中的表达及意义  

Expression and Significance of GRP78 in liver cancer

作　　者：周臣敏 董浦江[2] 付小利 

机构地区：[1]綦江区人民医院,重庆401420 [2]重庆医科大学附属第一医院,重庆400016 [3]潼南县人民医院,重庆402660

出　　处：《国际检验医学杂志》2013年第7期809-810,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨葡萄糖调节蛋白78(GRP78)在肝癌组织中的表达及意义。方法用蛋白印迹法检测73例肝癌组织、23例肝硬化组织、8例正常肝组织的GRP78蛋白表达情况。SABC免疫组化法测定肿瘤组织微血管密度。结果 GRP78蛋白在肝癌组织中的表达明显高于肝硬化及正常肝组织,GRP78蛋白高表达肝癌组织的转移率、微血管密度明显高于低表达组及未表达组(P<0.01)。结论 GRP78蛋白在肝癌组织中的表达呈增高趋势,提示其参与了肝癌的发生过程,GRP78蛋白高表达与肝癌细胞转移有关。Objective To study the expression and significance of GRP78 protein in liver cancer. Methods The Western blot was carried out to detect the level of GRP78 protein from 73 liver cancer,23 cirrhosis and 8 normal liver, and the density of blood vessels in liver cancer was studied by SABC immunohistochemistry. Results The expression of Grp78 in the cancer tissue was sig- nificantly higher than that of the cirrhosis and normal liver, transfer rate of tumor cells and density of blood vessels in higher ex- pression of GRP78 group were higher than that in other two group（P〈0.0 1）. Conclusion The expression of Grp78 showed a gradual increase tendency in the order of from normal tissue,the cirrhosis to carcinoma. Grp78 was involved in the development of liver carcinoma. The GRP78 protein was highly expressed might be play a key role in liver cancer cell metastasis.

关 键 词：肝肿瘤 热休克蛋白质类 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]