重症监护室鲍曼不动杆菌连续11年耐药谱动态观察  

Prevalence of acinetobacter baumannii causing infections in intensive care:a 11-year dynamic observation

作　　者：李文青[1,2] 吴伟元 卢月梅[1,2] 吴劲松 程锦娥[1,2] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院检验科,广东深圳518020

出　　处：《国际检验医学杂志》2013年第8期972-973,975,共3页International Journal of Laboratory Medicine

基　　金：深圳市科技计划项目(201103336)

摘　　要：目的了解重症监护室(ICU)鲍曼不动杆菌临床感染情况和耐药性变迁,为合理应用抗菌药物和预防控制医院感染提供依据。方法回顾性分析2001年1月至2011年12月ICU临床标本中分离的733株鲍曼不动杆菌资料,用WHONET5.4分析鲍曼不动杆菌的耐药率变迁。结果 ICU鲍曼不动杆菌痰标本所占比例最高(69.58%),对临床常用的15种抗菌药物耐药率总体呈上升趋势;并且2009年呈飞跃式上升且2010和2011年居高不下,对除米诺环素和头孢噻肟外的13种抗菌药物的耐药率及多药耐药鲍曼不动杆菌和泛耐药鲍曼不动杆菌的分离率显著高于非ICU(P<0.01)。结论 ICU鲍曼不动杆菌11年对临床常用抗菌药物的耐药性显著增强,耐药形势非常严峻,应当加强感染控制。Objective To understand the distribution characteristics and drug resistance of acinetobacter baumannii clinical iso-lates in ICU, so as to provide reference for rational use of antibiotics and infection control. Methods The result of drug susceptibili-ty and clinical distribution of acinetobacter baumannii from 2001 January to 2011 December in ICU of Shenzhen People＇s Hospital were analyzed. The antimicrobial resistance rates were analyzed by WHONET 5.4. Results Acinetobacter baumannii strains in ICU were mainly isolated from sputum （69.58 %）. The resistance rate of acinetobaeter baumannii to 15 kinds of drugs appeared increas-ing too. They had been increased sharply in 2009 and remained high very much in 2010 and 2011. The resistance rates to 13 kinds of drugs except minocycline and cefotaxime in ICU were higher than those in non-ICU （P〈0.01） ,The isolation rates of multiple drug resistance and pan drug resistant in ICU were higher than those in non-ICU too （P〈0.01）. Conclusion The clinical resistance of acinetobacter baumannii in ICU to commonly used antibiotics significantly increased from 2001 to 2011. acinetobacter baumannii in ICU has severe drug resistance,infection control should be enhanced in ICU.

关 键 词：不动杆菌属 抗菌药 药物耐受性 重症监护病房 

分 类 号：R446.5[医药卫生—诊断学]