介入治疗对急性冠状动脉综合征患者血小板活化及炎症因子的影响  

Effects of Percutaneous Cornary Intervention on Inflammatory Factors and Platelet Activation in Patients with Acute Coronary Syndrome

作　　者：陈申杰[1] 朱敏[1] 许海宾[1] 黄兆铨[1] 

机构地区：[1]浙江省中医院心内科,310006

出　　处：《心脑血管病防治》2013年第2期99-101,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨介入治疗(PCI)对急性冠脉综合症(ACS)患者血小板活化及炎症因子的影响。方法回顾性分析45例PCI治疗的ACS患者的血小板活化及炎症因子指标检测结果。结果 45例患者PCI术后血小板活化指标CD62p、CD63及炎症因子IL-6、Hs-CRP表达浓度均显著高于术前(P<0.01),且于术后24h达最高(P<0.01),而术后72h、96h则呈现出降低趋势(P<0.01),至96h已降至术前30min水平(P>0.05)。结论 PCI治疗ACS过程中,可能因介入操作造成血管内皮损伤,导致血小板功能活化与炎症因子表达增多,可增加血栓形成与再狭窄(RS)的发生率。Objective To discuss the effects of pereutaneous comary intervention（PCI） on inflammatory factors and platelet activation in patients with acute coronary syndrome（ACS）. Methods Inflammatory factors （IL-6 and Hs-CRP） and platelet activation （CD62p and CD63） were detected in 60 paitients who accepted PCI with ACS before and after the operation, then the changes were analyzed. Results IL-6, Hs-CRP, CD62p, and CD63 after PCI were significantly higher than before （ P 〈 0.01 ）, and 24 hours after PCI were significantly higher than the other times （ P 〈 0.01 ）, decreased at 72 hours after PCI, and down to the preoperative level at 96 hours after PCI. Conclusions PCI can lead to platelet activation and expression of inflammatory cytokines increased because of vascular en- dothelial injury, and increase the thrombosis incidence and RS.

关 键 词：介入治疗 畸形冠脉综合症 血小板活化 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]