合生元对高脂大鼠模型降脂作用研究  

Research on hypolipidemic effect of synbiotics in Hyperlipidemia rats

作　　者：程秀芳[1] 刘虹[1] 王丛丛[1] 李丹[1] 谢莉敏[1] 谷巍[1] 

机构地区：[1]山东宝来利来生物工程股份有限公司,山东泰安271000

出　　处：《药学研究》2013年第3期138-141,共4页Journal of Pharmaceutical Research

摘　　要：目的探讨两株益生菌(嗜热链球菌Streptococcus thermophiluss、植物乳杆菌Lactobacillus plantarum)和两种益生元混合而成的合生元对高脂大鼠降血脂的影响。方法采用Wistar大鼠建立脂代谢紊乱模型,设高、中、低剂量组(分别是2.25、0.45、0.09 g.kg-1)、一个模型组和一个正常组,灌胃30天后取血,采用生化分析仪检测其对大鼠血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)水平,并检测肝脾肾指数。结果合生元对大鼠的采食量、肝脾肾指数无影响;模型组中大鼠的TC和TG与正常组比较有显著性的升高(P<0.01),说明模型成立;三个合生元剂量组(给药组)的TC和TG比模型组显著性的降低(P<0.01)。结论合生元具有很好的降血脂作用。Objective To investigate the hypolipidemic effect of synbiotics composed of two strains of probiotics （ Streptococcus thermophilus ,Lactobacillus plantarum） and two kinds of prebiotics in Hyperlipidemia rats. Methods Build lipid metabolism disorder model using Wistar rats, set up three dose groups respectively 2.25,0.45,0.09 g .kg^-1 , a model group and a normal group, Gavage 30 days, Detect the level of total cholesterol （ TC ） , triglyceride （ TG ） and high - density lipoprotein cholesterol（ HDL - C ） of rat serum using Biochemical kit, and detect the liver spleen and kidney index. Results Synbiotics had no effects on feed intake and liver spleen kidney index. Three synbiotics dose groups （ treatment group ） could significantly reduce the levels of total cholesterol （ TC ） and triglyceride （ TG ） compared with the control group. TC and TG of rats in the model group compared with normal groups were significantly increased（ P 〈 0.01 ） , showed that the model was established, three synbiotics dose group （ treatment group） of TC and TG than that in the model group significantly decreased （ P 〈 0.01 ）. Conclusion Synbiotics had good function of reducing blood lipid.

关 键 词：益生菌 合生元 模型 降血脂作用 

分 类 号：R965.2[医药卫生—药理学]