苏木乙酸乙酯提取物对动脉粥样硬化模型大鼠血清MCP-1的影响  

Effects of Sappan Lignum Ethylacetate Extracts in MCP-1 Expression of Atherosclerotic Rats

作　　者：邢露茗[1] 张芯[1] 李光[1] 杨建飞[1] 周亚滨[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药信息》2013年第2期104-105,共2页Information on Traditional Chinese Medicine

基　　金：国家科技重大专项课题(2009ZX09103)

摘　　要：目的:观察苏木乙酸乙酯提取物对动脉粥样硬化模型大鼠血清MCP-1的影响。方法:随机挑选8只大鼠作为空白对照组,其余大鼠建立动脉粥样硬化模型,将其随机分为模型对照组、辛伐他汀组、苏木乙酸乙酯提取物高剂量组、中剂量组、低剂量组,每组8只,药物治疗7天后采血测定血清MCP-1的水平。结果:与模型组比较,高剂量组、中剂量组、辛伐他汀组MCP-1含量均降低,差异具有统计学意义(P<0.05);与辛伐他汀组比较,高剂量组、中剂量组差异无统计学意义(P>0.05)。结论:苏木乙酸乙酯提取物可降低动脉粥样硬化模型大鼠血清MCP-1的含量,可能通过抑制炎症反应对动脉粥样硬化起到一定作用。Objective： To observe the role of Sappan Lignum Ethylacetate Extracts in MCP- 1 expression of atherosclerotic rats. Methods： 8 rats were randomly selected as the blank control group. Establish the model of atherosclerotic rat, then divide them into five groups （model group, simvastatin group, high dose group, mid- dle dose group and low dose group）. Each group contains eight cases. Then give a garage of 7 days with drugs and detect the MCP - 1 expression in serum. Result： MCP - 1 serum levels decreased in high dose group, middle dose group, simvastatin group compared with model group （ P 〈 0.05 ）. And we found no significant differences between high dose group, middle dose group and simvastatin group （ P 〉 0.05 ）. Conclusion ： Sappan Lignum Ethylacetate Extracts can decrease MCP - 1 serum level in atherosclerotic rats, it may play a role in the process of atherosclerosis by inhibiting the inflammatory response.

关 键 词：苏木 动脉粥样硬化 MCP-1 

分 类 号：R285.5[医药卫生—中药学]