闽南地区女性生殖异常患者染色体核型分析  

Analysis on chromosome of female patients with reproductive abnormalities in southern Fujian area

作　　者：王厚照[1] 马芳芳[1] 刘芳[1] 史彩虹[1] 田艳[1] 

机构地区：[1]解放军第174医院检验科,福建厦门361003

出　　处：《临床军医杂志》2013年第4期402-404,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨染色体异常与生殖异常的关系。方法对1 046例女性不孕不育患者进行外周血淋巴细胞培养,G显带进行染色体核型分析。结果不孕不育患者中检出染色体异常核型68例,异常率为6.50%(68/1 046)。68例染色体异常患者中常染色体结构异常42例,占61.76%(42/68);性染色体异常26例,占38.24%(26/68),其中性染色体数目异常16例,占61.54%(16/26);性染色体结构异常10例,占38.46%(10/26)。结论生殖异常与染色体异常关系密切,对久治不愈的不孕不育患者进行染色体检查是有必要的。Objective To explore the relationship between chromosome abnormality and infertility. Methods Examination, including lymphocyte culture and chromosome G-banding karyotype analysis, was carried out on 1 046 female patients with infertility. Results Abnormal chromosomes were found in 68 （6.50% , 68/1 046） patients, 42 of whom （61.76% , 42/68） had abnormal euchromosomes, and 26 of whom （38.24% , 26/68） had abnormal sex chromosomes. Out of the 26 ones with abnormal sex chromosomes, 16 were abnormal in the number of sex chromosomes, accounting for 61.54% （16/26） , and 10 were abnormal in sex chromosome structure, accounting for 38.46% （10/26）. Conclusion There is a closely relationship between abnormal chromosomes and infertility in southern Fujian area. It is very necessary that those with infertility be analyzed on chromosomes.

关 键 词：染色体 女性不孕不育 

分 类 号：R169[医药卫生—公共卫生与预防医学]