MDRD与CKD-EPI方程在我国早期慢性肾脏病患者中应用的比较  

Comparison of MDRD and CKD-EPI equation in Chinese patients with early chronic kidney disease

作　　者：袁红波[1] 楼季庄[1] 

机构地区：[1]南京医科大学附属南京医院南京市第一医院血液净化中心,江苏南京210006

出　　处：《现代医学》2013年第4期245-247,共3页Modern Medical Journal

摘　　要：目的:评价CKD-EPI方程在中国早期肾脏病患者人群中的适用性。方法:选择528例南京地区慢性肾脏病(CKD)患者,以CKD-EPI方程与改良简化MDRD方程计算的肾小球滤过率(GFR)进行CKD分期,比较CKD-EPI方程与改良简化MDRD方程之间CKD各分期人数的百分比以及GFR(cGFR和mGFR)水平。结果:CKD-EPI方程与改良简化MDRD方程相关性良好(r=0.755,P<0.001);根据CKD-EPI方程和改良简化MDRD方程对患者CKD分期,两者间CKD 1期、CKD 2期人数的百分比差异有统计学意义(P<0.05),CKD 3期人数的百分比差异无统计学意义(P>0.05);但CKD-EPI方程计算得出的平均cGFR值低于改良简化MDRD方程计算得出的平均mGFR值,两者差异有统计学意义(P<0.05)。结论:当GFR>60 ml.min-1.1.73-2时,与改良简化MDRD方程比较,CKD-EPI方程存在低估GFR的倾向,其是否能否取代简化MDRD方程尚需进一步研究。Objective： To evaluate the applicability of the CKD-EPI equation in the Chinese patients with early chronic kidney disease （CRF）. Methods： Five hundred and twenty-eight patients with CRF in Nanjing area were included in this study. First, the patients were classified in CKD stage according to CKD-EPI equation estimating GRF（cGFR） and the simplified MDRD equation estimating GRF（eGFR） respectively. Then percentages of CKD stages and GFRs were compared respectively according to the results. Results： The two methods estimating GFRs had significant correlation （r = 0. 755, P 〈 0. 001 ）. There were significant difference in the percentage of CKD 1 between the two, as well as the percentage of CKD 2 （P 〈 0.05 ）. While there was no significant difference in the percentage of CKD 3 （P 〉0.05 ）. The average of cGFR was lower than the mGFR and there was significantly differences（ P 〈 0.05 ）. Conclusions： It exists a tendency to underestimate GFR in Chinese patients with CKD of CKD-EPI equation compared with the simplified MDRD equation when GFR 〉 60 ml ·min^-1· 1.73-2. More further studies are still needed to prove whether CKD-EPI equation could replace the simplified MDRD equation.

关 键 词：慢性肾脏病 肾小球滤过率 CKD—EPI方程 改良简化MDRD方程 

分 类 号：R692.6[医药卫生—泌尿科学]