Antimicrobial, anticancer and DNA binding studies of transition metal(Ⅱ)complexes containing 2-phenyl-4-selenazole carboxylic acid  

作　　者：GUAN QuanYin SHI Xia SHEN JinBei ZHAO GuoLiang 

机构地区：[1]College of Chemistry and Life Sciences, Zhejiang Normal University [2]Zhejiang Normal University Xingzhi College

出　　处：《Science China Chemistry》2013年第5期588-594,共7页中国科学（化学英文版）

基　　金：financially supported by Natural Science Foundation of Zhejiang Province (Y4080256)

摘　　要：Three novel transition metal complexes [ML2（phen）]＇H20 （M= Mn, Co, Zn; HL= C10H702NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline） 1-3 were synthesized and characterized by elemental analysis, IR spectra. Their crystal structures were deterimined by single-crystal X-ray diffraction method. The antibacterial activities of the complexes against five species of bacteria, Escherichia coli （E. coli）, Staphylococcus epidermidis （S. epidermidis）, Staphylococcus aureus （S. au- reus）, Acinetobacter baumanii （A. baumanii） and Streptococcus viridans （S. viridans）, were tested respectively. The anticancer activities of the complexes against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied. The interactions between the complexes and DNA were studied by ethidium bromide （EB） fluorescent probe.三新奇转变金属建筑群[ML2 (phen )] ？？

关 键 词：2-phenyl-4-selenazole carboxylic acid transition metal complex antibacterial activity anticancer activity DNA binding 

分 类 号：O641.4[理学—物理化学] TQ462.8[理学—化学]