New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(Ⅱ)-arene complex  

作　　者：LI ShuiHong WU ChangYu TANG Xiao GAO ShengPing ZHAO XinQing YAN Hong WANG XueMei 

机构地区：[1]State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University [2]School of Chemistry and Chemical Engineering, Nanjing University [3]School of Life Science and Biotechnology, Dalian University of Technology

出　　处：《Science China Chemistry》2013年第5期595-603,共9页中国科学（化学英文版）

基　　金：the financial support from National Nature Science Foundation of China (21175020);National Key Basic Research Program (2010CB732404);Graduate Research and Innovation Program of Jiangsu Province (CXLX_0145)

摘　　要：Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium（II）-arene complex （FcRuSB）. Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant （MDR） clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins （EMP） of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.

关 键 词：bacterial biofilms carborane ruthenium(Ⅱ)-arene complex antibiotic resistance 

分 类 号：TQ465[化学工程—制药化工]