兔VX2肝种植瘤盐酸消融治疗两周后CT灌注参数分析  

The Rabbit Liver VX2 Tumor Ablation Treatment of Hydrochloric Aciid of CT Perfusion Parameters After 2 Weeks

作　　者：赵欣 张明敏 张强 刘照信 满都花 

机构地区：[1]包头肿瘤医院检验科放射科,内蒙古包头014030

出　　处：《内蒙古医学杂志》2012年第12期1416-1420,共5页Inner Mongolia Medical Journal

摘　　要：目的:肝癌的盐酸消融治疗是一种局部、微创、安全、可以重复进行的治疗方法,与手术相比,能减少对正常组织的损伤,避免开腹手术对患者的打击,减少手术相关发病率和死亡率,并且花费低、住院时间短。盐酸消融对高风险、不能手术的患者很大程度上能起到代替手术的作用。目前,在评估盐酸消融疗效方面还存在争议,但是随着技术的进步和经验的累积,盐酸消融必将在腹部肿瘤的治疗中有着更加广阔的前景。本实验通过建立兔VX2肝种植瘤模型探讨了不同时相VX2肿瘤的CT灌注参数特征,为进一步评价功能影像学在肝种植瘤盐酸消融疗效预测提供实验依据,探讨血流动力学参数对盐酸消融治疗疗效预测的可能性及血流动力学参数变化的特点。本实验通过观察兔肝VX2种植瘤盐酸消融治疗2周后CT灌注参数的变化及盐酸消融组(治疗组)与空白对照组(对照组)CT灌注参数的变化进而为临床肝癌治疗提供科学的依据。方法:新西兰大白兔20只,采用组织块种植法制成兔肝VX2模型,随机分为治疗组和对照组,2周后治疗组兔接受盐酸消融治疗。于治疗后14 d分别对两组行CT灌注扫描动态监测。选取肿瘤中央区、周边区和瘤周正常肝组织的感兴趣区(ROI),分别测量灌注值(PV)、强化峰值增量(PEI)、达峰值时间(TTP)、血容量(BV)。统计学处理采用独立样本的t检验及自身配对t检验分析治疗组与对照组及每组自身灌注参数的变化。结果:治疗组与对照组肿瘤中央区及瘤周区PV、PEI、BV存在明显差异(P<0.05);治疗组与对照组肿瘤中央区及瘤周区TTP无显著差异(P>0.05)。结论:PV、PEI、BV灌注参数的变化可以反映兔VX2肝移植瘤内部血流动力学的差异,早期区别肿瘤细胞血流稀疏区和增殖旺盛的集区,为从微观角度观察兔VX2肝移植瘤盐酸消融提供了基础,对临床盐酸消融患者提高生活质量及远期�Objective：Of hydrochloric acid ablation of liver cancer is a local, minimally invasive, safe, and can repeat the treatment, compared with surgery, can reduce the damage to normal tissue, avoid blow open surgery for patients, reduce surgical - related morbidity andmortality, and costs, shorter hospital stay. Hy- drochloric acid ablation of high - risk patients with inoperable largely play a role instead of surgery. In assessing hydrochloric ablation efficacy is still controversial, but with the advances in technology and experience accumu- lated, hydrochloric acid ablation in the treatment of abdominal tumors will have broader prospects. The experi- mental rabbit VX2 hepatic implantation tumor model to explore the characteristics of VX2 tumors at different phases of CT perfusion parameters, learning in the liver the implanted tumor hydrochloric ablation efficacy pre- dicted to provide experimental evidence for further evaluation of functional imaging, to explore hemodynamic pa- rameters hydrochloric ablation characteristics of the treatment efficacy predicted the possibility of bemodynamicparameters change. Changes in CT perfusion parameters of the experiment by observing rabbit liver VX2 im- planted tumor hydrochloric two weeks after ablation, and hydrochloric ablation group （treatment group） and the control group （control group） CT peHusion parameters change in turn provide a scientific basis for the clinical treatment of liver cancer . Method：20 methods of New Zealand white rabbits using tissue block cultivation of the legal system into a rabbit liver VX2 model were randomly divided into treatment and control groups, two weeks after treatment of the rabbits receiving hydrochloric acid ablation treatment. Before treatment, 7d after two sets of CT perfusion scan, dynamic monitoring of one week. Embraced the Dutch PHILIPS of Brilliance 16 - slice spiral CT. U.S. the MEDRAD binoculars high - pressure syringe. Image post - processing for dedicated perfu- sion software and EBW 4.0 workstation. Select the

关 键 词：肝种植瘤 动物模型 螺旋CT 灌注参数 

分 类 号：R333[医药卫生—人体生理学] R733[医药卫生—基础医学]