磁刺激穴位对大脑功能网络的影响  

Brain Functional Network Influenced by Magnetic Stimulation at Acupoints

作　　者：尹宁[1] 徐桂芝[1] 于洪丽[1] 周茜[1] 郭磊[1] 

机构地区：[1]河北工业大学生物医学工程系,天津300130

出　　处：《中国生物医学工程学报》2013年第2期184-190,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(50877023);高等学校博士学科点专项科研基金(20121317110002)

摘　　要：基于复杂网络理论,研究磁刺激穴位时大脑功能连接的变化情况。利用互相关和互信息方法,分析了7名被试内关穴磁刺激前、刺激中、刺激后同步脑电信号的通道间关联特性,构建了大脑功能网络,并利用复杂网络分析方法对其进行了中心化程度评价,分析了几种状态下的关键脑区。结果表明:1 Hz刺激与刺激前相比,顶叶内部、顶叶与中央区节点间的关联程度发生了统一增强,额叶与枕叶、额叶与顶枕叶节点间的关联程度发生了统一减弱;3 Hz刺激与刺激前相比,统一增强的区域集中在额叶内部、中央区内部、额叶与中央区、额叶与顶叶、额叶与颞叶、中央区与颞叶、中央区与顶叶节点之间。度值较大的节点主要分布在额叶和中央区,介数值较大的节点主要分布在顶叶、中央区以及顶枕区。此研究有助于揭示磁刺激穴位对大脑功能网络的影响。Study on the changes of brain functional connections during acupoint magnetic stimulation based on the complex network theory. Using cross-correlation and mutual information method, the channel relationships of EEG signals of seven subjects were analyzed before, during and after magnetic stimulation on acupoint and the corresponding brain functional networks were constructed. The centralization indices were calculated using complex network analysis method and then the key brain regions of each stimulation mode were obtained. The results showed that comparing with the functional network before stimulation, the relationships between the nodes of parietal lobe and central region were unified enhanced during 1 Hz stimulation, meanwhile, the relationships among the nodes of frontal lobe, occipital lobe and top occipital lobe were unified weakened. However, the unified enhanced area during 3 Hz stimulation concentrated among the nodes of frontal lobe, central region, parietal lobe and temporal lobe. Nodes with high degree were mainly distributed in the frontal lobe and the central, while the nodes with high betweenness centrality were mainly distributed in the parietal lobe, the central and top occipital area. This study helps to reveal the influence of acupoint magnetic stimulation on brain functional networks.

关 键 词：磁刺激 穴位 脑功能网络 度 介数 

分 类 号：R318.04[医药卫生—生物医学工程]