MTT评价代谢综合征患者颈动脉粥样斑块生物力学特性的研究  

Quantitative Assessment of Atherosclerosis Plaque Biomechanics Patients with Metabolic Syndrome Using Multiple Tracking Techniques

作　　者：解园星[1,2] 王洪云 王志蕴[1,2] 申洪明[1,2] 刘莹[1,2] 席振创[1,2] 

机构地区：[1]山东省医学科学院附属医院内六科,山东省济南市250031 [2]济南大学山东省医学科学院医学与生命科学学院,山东省济南市250200 [3]滨洲市人民医院心内科,山东省滨州市256600

出　　处：《中国动脉硬化杂志》2013年第4期320-324,共5页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金面上项目(ZR2010HM084)

摘　　要：目的应用多道示踪技术探讨代谢综合征患者颈动脉正常部位和斑块部位、硬斑块和软斑块及斑块肩部和纤维帽顶部的径向速度、应变、应变率的变化规律。方法对126例代谢综合征患者和60例正常人双侧颈动脉进行高频超声检查,检测颈动脉内膜中层厚度;多道示踪技术示踪颈动脉无斑块部位和斑块部位、斑块肩部和纤维帽顶部径向速度、应变和应变率,并进行分组分析。结果代谢综合征组颈动脉内膜中层厚度高于对照组,差异有统计学意义(P<0.05);对照组颈动脉收缩期最大径向速度高于代谢综合征组颈动脉无斑块部位的测定值,差异有统计学意义(P<0.05);软斑块收缩期最大径向速度、最大应变率分别高于硬斑块,差异具有统计学意义(P<0.05);颈动脉斑块肩部收缩期最大径向速度、应变率分别高于斑块纤维帽顶部,差异亦具有统计学意义(P<0.05)。结论多道示踪技术可早期检测代谢综合征患者的颈动脉粥样硬化并准确评价动脉斑块生物力学特性,为在上游、早期有针对性干预心脑血管疾病提供了量化指标依据。Aim Using multiple tracking techniques （MTT） to analyze and evaluate the changes of atherosclero- sis plaque biomechanics patients with metabolic syndrome （MS）. Methods 126 patients with metabolic syndrome ac- cording to the diagnostic standard of International Diabetes Federation （IDF） and 60 normal subjects were examined using multiple tracking techniques, which dynamic imaging was acquired from all subjects and all above images were stored for off-line analysis with dedicated MTI＂ workstation and all mechanical parameters were collected, including the peak velocity, strain and strain rate of plaque and without plaque, the cap and shoulder of plaque, intima media thickness. The above parameters at different points of carotid intima were compared and studied. Results The level of intimal-media thick- ness （IMT） in MS patients was higher than that in normal control contract （P 〈 0. 05 ）. The systolic maximum velocity and strain of carotid with normal control were significantly higher than that of carotid without plaque with MS （P 〈 0. 05）. The systolic maximum velocity and strain rate of soft plaque were increased significantly than those of hard plaques. The systolic maximum velocity and strain rate of fabric cowl in the plaque were significantly lower than the shoulder of the plaques （P 〈 0. 05）. Conclusion The MTI＂ could detect the elasticity of blood vessel wall, sclerosis and the mecha- nism asynchrony of the carotid artery, and then could be used as the predictive parameter and quantization for atherosclero- sis and vulnerable plaque instability.

关 键 词：多道示踪技术 代谢综合征 生物力学 易损斑块 

分 类 号：R5[医药卫生—内科学]