40mg与10mg阿托伐他汀对缺血性心肌病患者血清前列环素及血小板活化影响的比较  

Comparison of 40 mg Versus 10 mg Atorvastatin on the Levels of Serum Prostacyclin and Platelet Activation in Patients with Ischemic Cardiomyopathy

作　　者：卓裕丰[1,2] 许顶立[1] 程颖 黄冰生[1,2] 解强 林桂雄 

机构地区：[1]南方医科大学南方医院心血管内科,广东省广州市510515 [2]广州市番禺区何贤纪念医院心血管内科,广东省广州市511400

出　　处：《中国动脉硬化杂志》2013年第4期341-344,共4页Chinese Journal of Arteriosclerosis

基　　金：广东省广州市卫生系统一般引导项目(2009-YB-186)

摘　　要：目的比较40 mg与10 mg阿托伐他汀对缺血性心肌病患者血清前列环素及血小板活化的影响。方法选择2008年3月至2010年6月在我院心内科住院确诊的缺血性心肌病患者77例,患者随机分为两组:阿托伐他汀10 mg/d治疗组38例和40 mg/d治疗组39例。随访期1年,所有研究对象在初始及随访结束时两次行肌酶、谷丙转氨酶、血脂、血小板、血清血小板活化因子、6-酮-前列素F1α及血栓素B2水平检测,并记录两组患者药物不良反应的发生率。结果研究结束时,与阿托伐他汀10 mg/d治疗组比较,阿托伐他汀40 mg/d治疗组血清总胆固醇、低密度脂蛋白胆固醇、血清血小板活化因子及血栓素B2水平水平明显降低,6-酮-前列素F1α水平明显升高(P<0.05);两组间血小板、血清肌酸激酶、谷丙转氨酶水平及药物不良反应比较差异无显著性(P>0.05)。结论与10 mg/d阿托伐他汀治疗比较,40 mg/d阿托伐他汀可能明显升高缺血性心肌病患者血清前列环素水平,降低患者血小板活化水平。Aim To investigate the differences of 40 mg versus 10 mg atorvastatin on the levels of serum prosta- cyclin and platelet activation in patients with ischemic cardiomyopathy （ICM）. Methods 77 patients with ICM in the Department of Cardiology were recruited to this study from March 2008 to June 2010. Patients were randomly divided into two groups ： l0 mg/d atorvastatin group （ n = 38 ） and 40 mg/d atorvastatin group （ n = 39 ）. All subjects were followed up for 1 year. The levels of serum glutamic-pyruvic transaminase, creatine kiiiase, lipids, platelet, platelet activating factor （PAF） , 6-keto-prostaglandin Flct（6-Keto-PGFltx） and thromboxane B2 （TXB2） were examined in all subjects at baseline and at the end of study. The incidences of adverse reactions in two study groups were taken down. Results At the end of this study, the levels of serum total cholesterol, low density lipoprotein cholesterol, TXB2, TXB2/6-Keto- PGF1 ct, PAF were significantly decreased and 6-Keto-PGFlct were significantly increased in 40 mg/d atorvastatin group in comparison with 10 mg/d atorvastatin group （P 〈 0. 05 ）. There were no significant differences between the two groups on the levels of serum glutamic-pyruvic transaminase, creatine kinase, platelet and the incidences of adverse reactions for medicines. Conclusions 40 mg/d atorvastatin might significantly decrease the levels of platelet activation and in- crease the levels of serum prostacyclin in patients with ICM in comparison with 10 mg/d atorvastatin.

关 键 词：阿托伐他汀 缺血性心肌病 前列环素 血栓素 血小板活化因子 

分 类 号：R5[医药卫生—内科学]