超级酶基因治疗在阴茎康复中的应用  

Advances in SuperEnzyme gene therapy in penile rehabilitation

作　　者：秦锋(综述)[1] Run Wang(审校) 袁久洪(审校)[1,3] 

机构地区：[1]四川大学华西医院,再生医学研究中心,四川成都610041 [2]Deaprtment of Urology,the University of Texas Medical Center at Houston,Houston 77030,USA [3]四川大学华西医院泌尿外科,四川成都610041

出　　处：《中华男科学杂志》2013年第4期350-354,共5页National Journal of Andrology

基　　金：国家自然科学基金(81270691和81170565);四川省科技支撑计划(2012SZ0151)~~

摘　　要：勃起功能障碍(ED)是前列腺癌根治术后常见的并发症。虽然阴茎康复的概念已被临床工作者广为接受,但目前常用的阴茎康复方法仍存在疗效欠佳、费用高、使用不方便和患者依从性差等亟待解决的问题。阴茎勃起是阴茎海绵体平滑肌松弛、动脉扩张等完整过程。前列环素(PGI2)是诱导平滑肌松弛最主要的血管保护剂。但PGI2极不稳定,不能直接给药。超级酶是一个创新的产品,它把生成PGI2的两种酶(环氧化酶和PGI合成酶)直接联系在一起。超级酶在阴茎组织能持续性、特异性、靶向性的促进PGI2合成,帮助前列腺癌根治术后ED患者的阴茎康复。该疗法在阴茎康复及ED治疗上具有广阔的前景,本文就目前该新疗法在阴茎康复中的研究进行了总结。Erectile dysfunction （ED） is an almost unavoidable complication of radical prostatectomy. At present, though the concept of penile rehabilitation （PR） is accepted by most clinicians, the outcomes of erectile function recovery vary widely. Prostacyclin （PGI2） is a prostanoid and a main vasoproctector which induces smooth muscle relaxation, but not used for replacement therapy because of its high unstability. SuperEnzyme is capable of continuous, specific and targeted promotion of PGI2 synthesis, and helps PR in ED patients after radical prostatectomy. SuperEnzyme gene therapy has a promising prospect for PR and the management of ED. This review updates SuperEnzyme gene therapy in PR.

关 键 词：勃起功能障碍 超级酶 基因治疗 前列环素 环氧化酶 阴茎康复 

分 类 号：R698.1[医药卫生—泌尿科学]