间质性肉芽肿性药物反应  

Interstitial Granulomatous Drug Reaction to Sanqi Panax Notoginseng

作　　者：杜旭峰[1] 邵明华[1] 顾永[1] 张国龙[1] 施和建[1] 

机构地区：[1]南京医科大学附属无锡市人民医院皮肤科,江苏无锡214023

出　　处：《临床皮肤科杂志》2013年第5期289-291,共3页Journal of Clinical Dermatology

摘　　要：报告1例间质性肉芽肿性药物反应。患者男,73岁。因躯干四肢出现暗红色丘疹、斑块1个月就诊。发病前因脑梗死口服血塞通软胶囊2个月,后未经特殊治疗皮疹缓慢消退。实验室和辅助检查均正常。皮损组织病理学检查显示基底细胞液化变性,真皮间质及血管周围弥漫性肉芽肿性改变,浸润的炎性细胞主要为组织细胞、上皮样细胞、淋巴细胞、嗜酸性粒细胞及多核巨细胞,并可见部分异形淋巴细胞。4个月后患者静脉滴注血塞通注射液后再次出现类似皮损。诊断:间质性肉芽肿性药物反应。A case of interstitial granulomatous drug reaction is reported. A 73-year-old male retiree presented with asymp- tomatic, dark-red macule, papules and plaques on the trunk and extremities for one month after orally taking Sanqi Panax Notoginseng soft capsules for about 2 month for brain infarction. All the results of laboratory tests were normal. Histopatho- logical examination revealed liquefaction degeneration of basal ceils, diffuse interstitial and perivascular infiltration of histio- cytes, epithelioid cells, lymphocytes, eosinophils, multinucleated giant cells, some atypical lymphocytes and interface dermati- tis. Four months later the patient developed almost identical eruptions again after 5-day intravenous Sanqi Panax Notogin- seng injections. The diagnosis of interstitial granulomatous drug reaction （IGDR） caused by Sanqi Panax Notoginseng was reached according to the clinical manifestations, histopathological features and reproducible drug-associated eruptions.

关 键 词：药物反应 间质性肉芽肿性 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]